Cases from private practices - Papimi

CASE HISTORIES OF AIDS PATIENTS
Case histories of AIDS patients who received treatment with the PAP IMI 300
device.
Patient No. 1 Male, 32 years old Name initials : AG/KY Code number : 199
homosexual, HIV seropositive since 4-93.
Kaposi's sarcoma lesions in his arms and left leg since 6-94. Started zidovudine ( ZDV) and
interferon-A-2b in 8-94. Lesions worsened and PAP IMI treatments were applied in 2-95. Interferon
administration was then stopped but antiretroviral treatment was continued. Following the PAP IMI
application, the patient's skin lesions remained stable and have continued to remain stable up to now (12-
95). The patient feels better and stronger and he has gained weight. Consecutive CD4 counts (per mm3 )
were :360 (8-94), 266 (1-95), 455 (4-5), 576 (6 -95), 558 (10-95). Blood count and biochemical values
remained stable.
Patient No. 2 Female, 32 years old Name initials: IO/GE Code number : 99
,heterosexual, HIV seropositive since 9-89.
Herpes Zoster of right leg (12-89), hairy leucoplakia (3-90), oral thrush (2-94), Kaposi's sarcoma
lesions in her gums and palate (6-94). Interferon - A - 2b was administered concomitantly with
antiretroviral therapy, which was begun in 3-90 ( ZDV, DDI , DDC ). She was also receiving aerosolized
pentamidine ( allergic to cotrimoxazole ). On February 1995 she refused to take interferon any longer.
PAP IMI treatments were begun in February and applied for three months.
During interferon treatment and PAP IMI application, the oral lesions remained stable. Her CD4
counts (cells/mm3 ) were 187 (6-94), 60 (12-94) 235 (end of March 1995). But her compliance to the
treatment regimen was rather poor. After three months we lost touch with her as she failed to continue
her treatments. After a few months we learned that she was being followed up in another AIDS unit,
where she had presented pulmonary tuberculosis and brain infarcts. Her CD4 count had dropped below
50 cells/mm3. In the absence of PAP IMI treatments CD 4 count is observed always to fall and never
to spontaneously rise. So, although a CD4 count was not taken immediately prior to the commencement
of PAP IMI treatments in 2-95, it can be assumed that the CD4 count at that time was below 60, and
not above.
Patient No. 3 Male, 59 years old Name initials: MI/GE Code number : 261
homosexual, HIV seropositive since 2-94.
Adenocarcinoma of sigmoid colon (6-93). Left semicolectomy ( stage C2, Ashler-Coller). Metastatic
lesion in the liver (1-94). After the documentation of HIV-1 seropositivity, he is followed up in our
department. He then received chemotherapy (5-FU plus leucovorin), antiretroviral therapy and interferon
-A-2b. On May 1995 PAP IMI treatments were applied due to constant pain in the right upper
quadrant of his abdomen. Pain was significantly relieved and his general condition was improved. This
analgesic effect lasted for several weeks. Subsequently, his compliance to treatment was not very good.
Up to now he has shown no AIDS defining illness but other metastatic lesions appeared in the liver and
lumbar spine. CD4 counts (cells /mm3 ): 212 (2-94), 40 (10-94 ), 284 (6-95). Although a CD4 count was
not taken immediately prior to the commencement of PAP IMI treatments in 5-95, it can be assumed
that the CD4 count at that time was below 40, and not above (see Case 3).
Patients No. 4 Male, 31 years old Name initials: PA/ NI Code number : 281
bisexual, HIV seropositive since 1989.
56