Post coronary artery bypass graft surgery

First experience of local implantation of autologus CD 133+
bone marrow stem cell transplantation for myocardial
regeneration in Iran
Ahmadi H, Baharvand H, Kazemi Ashtiani S, Soleimani M, Sadeghian H, Majd
Ardekani J, Marzban M, Zareh N, Kouhkan A, Madani-Civi M, Namiri M and
Kamangari A
Tehran Heart Center, Medical Sciences/University of Tehran, Tehran, Iran Royan institute, stem cell
department, tehran, Iran.
Abstract
Background: Experimental studies suggest that autologus bone marrow stem cell
transplantation (CD 133+) in patients with myocardial infarction (MI) may improve
cardiac function. The aim of this study was to assess feasibility, safety of this therapy and
cardiac performance as well.
Methods: Between June 2004 - June 2005, 29 patients with history of acute myocardial
infarction within 3 months who were candidate for coronary artery bypass grafting
(CABG), were entered in our study. The patients randomly divided into groups: control
group (n=9, CABG alone) and BMC group (n=20, CABG with intramyocardial injection
of autologus CD 133+ bone marrow stem cell in the infracted border zone). For all
patients, dobutamine stress echo and thallium scan was performed before, 3 and 9 months
after CABG to determine improvement in regional viability and contractility of the heart.
Results: There were no significant differences between demographic factors of two
groups. Thallium scan and echocardiography reinvestigation showed improvement in
global LV function, regional wall motion and perfusion of infracted area. Left ventricular
ejection fraction (LVEF) improved from 34.3r1.5 to 38r1.3 in BMC group (p