DART-Agilent Vapur Interface Manual SI-300-A Rev 6 ... - IonSense

Setting the Source Type
The source setting in the MassHunter software is most likely set to “ESI,” which is the
default setting if the system has not detected an i-button present.
Change the source type to “Dual-ESI”.
The capillary (in the case of ESI) is at high temperature. You can increase/decrease the
temp inside the MassHunter software window (shown below in Figure 9).
Enter Dual-
ESI source
Figure 9: MassHunter Control program window
Optimal Parameters
IonSense recommends using the following operational settings:
Capillary Voltage: ~1000V
Drying Gas: 8.5 L/min (Important to keep H 2 O cluster formation low)
Fragmentor Voltage: 150-175V
Octapole Voltage:
o 250V for masses above 100 Da
o 100V for masses below 100 Da
If “Dual-ESI is not an option:
On older-version instruments, “Dual-ESI” is not an option in the software.
In this case:
1. Set the source type to “ESI”.
2. On the start button select:
Programs → Agilent- MassHunterWorkstation → Acquisition tools →
Instrument Configuration
3. Deselect LC
4. On the source button select "Do not wait for set-points to equilibrate"
DART-Agilent Vapur Interface Manual (SI-300-A Rev 6) 10