Risk Assessment – History and Future
Risk Assessment – History and Future
Risk Assessment – History and Future
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Margin of exposure (MOE)<br />
• DNA-reactive genotoxic carcinogens <strong>–</strong> assume no threshold<br />
• Linear, low-dose extrapolation is very uncertain<br />
• As an alternative, derive margin of exposure (MOE)<br />
• POD/Human exposure (measured or predicted)<br />
• Usually, POD = BMDL10 for animal data, BMDL1 or less for<br />
human data<br />
• MOE of >10,000 based on animal data <strong>–</strong> of low concern<br />
• Enables ranking <strong>and</strong> prioritisation of risks; assessment of<br />
outcome of different risk management options;<br />
communication of level of concern<br />
• NB: MOE concept is applicable to threshold toxicants<br />
• Interpretation of MOE
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