Risk Assessment – History and Future
Risk Assessment – History and Future
Risk Assessment – History and Future
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Advantages of focusing on MOA<br />
• Use of in vitro <strong>and</strong> in silico models to characterise key<br />
events<br />
• Development <strong>and</strong> application of mechanism-based<br />
biodynamic models to identify rate-limiting processes in<br />
modes of action<br />
• Underst<strong>and</strong>ing interindividual variability in the rate<br />
determining events may enable a true population<br />
threshold(s) to be identified<br />
• Characterisation of the population dose-response curve<br />
<strong>and</strong> identification of susceptibility factors<br />
• Development of mechanistically-informed biomarkers
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