Risk Assessment – History and Future

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The future of risk assessment • The basic principles of risk assessment will not change • Make the best use of all available information to inform policy to protect human health • The nature of the information for risk assessment will change to a more bottom-up approach • Uncertainty will increase, at least initially, as new approaches are evaluated • There is likely to be a move from “bright line” safety to levels of protection • Need to bound uncertainty • Society will increasingly have to make choices between risks <strong>and</strong> benefits, not all health-based • Need for adequate risk-benefit analysis methodology
Consider ….. • “Some aspects of reality might elude us because they are beyond human brains, just as surely as Einstein's ideas would baffle a chimpanzee.” - Martin Rees, Astronomer Royal (2010) • My appreciation to all at ILSI HESI, ILSI Europe, ILSI RF, IPCS, EFSA, JMPR, COT, COC, etc
Page 1 and 2: Risk Assessment - History and Futur
Page 3 and 4: Risk assessment • A scientific pr
Page 5 and 6: Threshold or non-threshold? NEL = N
Page 7 and 8: Risk assessment: threshold Hazard I
Page 9 and 10: Risk assessment: non-threshold effe
Page 11 and 12: Margin of exposure (MOE) • DNA-re
Page 13 and 14: Key event • An empirically observ
Page 15 and 16: Toxicity Testing in the 21st Centur
Page 17 and 18: Perturbation of toxicity pathways E
Page 19 and 20: Science and Decisions: Advancing Ri
Page 21: Advantages of focusing on MOA • U
Page 25: HESI Risk 21 - Key areas of focus

Risk Assessment – History and Future

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