Risk Assessment – History and Future
Risk Assessment – History and Future
Risk Assessment – History and Future
SHOW LESS
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
<strong>Risk</strong> assessment: non-threshold effect,<br />
e.g. DNA-reactive carcinogens<br />
Dose-response extrapolation<br />
100<br />
10<br />
Region of<br />
acceptable<br />
risk<br />
Region of<br />
experimental<br />
data<br />
% Response<br />
1<br />
0.1<br />
0.01<br />
0.001<br />
Multi-stage<br />
One hit<br />
Weibull<br />
Log-normal<br />
0.0001<br />
0.00001<br />
0.00001 0.0001 0.001 0.01 0.1 1 10 100<br />
Dose (mg/kg/day)
Change language