Risk Assessment – History and Future
Risk Assessment – History and Future
Risk Assessment – History and Future
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Perturbation of toxicity pathways<br />
Exposure<br />
Low Dose<br />
Tissue Dose<br />
Biologic Interaction<br />
Perturbation<br />
Higher Dose<br />
Higher yet<br />
Biologic<br />
Inputs<br />
Normal<br />
Biologic<br />
Function<br />
Early Cellular<br />
Changes<br />
How do we distinguish<br />
adaptive versus adverse<br />
(toxic) responses?<br />
Adaptive Stress<br />
Responses<br />
Cell<br />
Injury<br />
Morbidity<br />
<strong>and</strong><br />
Mortality
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