Fall 2011 - Institute of Medical Science - University of Toronto

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COMMENTARY Tell us what you think “Just a quick email to congratulate [your team] on the IMS Magazine. Very interesting content and nice to get a flavour of what else is happening at IMS.” – Colin McCartney, Associate IMS Member “Congratulations! The magazine looks brilliant.” – Santhosh, IMS student “[The magazine] looks great and the content is interesting and well put together… Looking forward to future issues.” – Wilfred Ip, IMS student “The magazine looks fantastic and reads extremely well with an excellent balance of interesting articles about students, faculty, staff and the life as an IMS student. ” – Dr. Karen Davis, IMS Associate Director What to look for next issue: The Surgical Management of Obesity by Dr. Teodor Grantcharov Commentary Dear Editor: I read the most recent (Summer 2011) edition of the IMS Magazine with great interest and enjoyed its focus on obesity/BMI. The magazine only briefly mentioned that BMI varies across ethnic groups. I would like to elaborate more on these ethnic variations using empirical evidence from my IMS PhD thesis findings. Many agree that the definition of obesity (BMI≥30) is inappropriate in non-white populations and that lower cutoff values are required for Asian populations, however no previous study has been able to pinpoint exactly what the BMI cutoff values should be for specific Asian ethnic groups. I therefore conducted a multiethnic cohort study of approximately 60,000 non-diabetic adults aged 30 years or over living in Ontario. Subjects were identified from Statistics Canada’s population health surveys and were followed for up to 12.8 years for diabetes incidence using record linkages to multiple health administrative databases. The study found that for the equivalent incidence rate of diabetes at BMI 30 in the White group, the BMI cutoff value was 24 in the South Asian group, 25 in the Chinese group, and 26 in the Black group. Moreover, the risk of diabetes was significantly higher among the South Asian (hazard ratio (HR): 3.40, p
LETTER FROM THE EDITOR Letter from the Editor I am always fascinated to learn about new scientific research. Having the privilege to study at the IMS has undoubtedly shown me the many ways in which science can be used to improve patient care - one of my own inspirations for starting the IMS Magazine. In the past three issues, we have explored a variety of research areas, from the genetics of childhood aggression, to multiple sclerosis and binge eating disorders. I have found them all very intriguing topics and rewarding to learn about. In this issue of the IMS Magazine, I would like to turn your attention to the topic of my area of research, prostate cancer. With the help of our very own world-class experts, Dr. Laurence Klotz, Dr. Neil Fleshner, Dr. Masoom Haider, and Dr. Vasundara Venkateswaran, we hope to provide you with a better understanding of prostate cancer prevention measures, management options, and future research strategies. Further, we give you a look into the Active Surveillance program, a management strategy initiated at Sunnybrook Hospital by Dr. Laurence Klotz, which is increasingly used worldwide for low-risk prostate cancer patients. In light of November, prostate cancer awareness month, I hope that this issue of the IMS Magazine will not only enhance your understanding of the disease, but also emphasize the importance of early detection. I encourage all those participating in the moustache-growing Movember charity event to submit your photos to the IMS Magazine Movember Contest (see page 43 for more information). Natalie Venier Editor-In-Chief Natalie Venier is a third year PhD Candidate at the Institute of Medical Science. She is currently studying prostate cancer chemoprevention at Sunnybrook Health Sciences Centre. I am also proud to announce the success of the Summer Student Writing Competition, which was met with great enthusiasm by this year’s SURP students. We received a number of excellent submissions, including one by Roman Shapiro, the winner of the competition. I encourage you to read through his interesting article on biases in Randomized Controlled Trials. We hope to continue to publish some of the other excellent submissions in future issues of the IMS Magazine. I would also like to take this opportunity to thank the IMS Community for their insightful feedback in response to the last issue, which I encourage you to read about in our new Commentary section. In closing, I would like to thank Dr. Allan Kaplan and the IMS department for their on-going support with the IMS Magazine. Additionally, I must acknowledge the phenomenal IMS Magazine Team, whose contributions are invaluable to its production. I’m looking forward to your feedback. Enjoy! Photo by Paulina Rzeczkowska Natalie Venier Editor-In-Chief, IMS Magazine IMS MAGAZINE FALL 2011 PROSTATE CANCER | 04
Page 1: IMSMAGAZINE FALL THINK, LEARN, DISC
Page 6 and 7: NEWS AT A GLANCE NEWS&VIEWS OCTOBER
Page 9 and 10: DIRECTOR’S MESSAGE Director’s M
Page 11 and 12: IMS SURP HIGHLIGHT IMS SUMMER INTER
Page 13 and 14: IMS SURP HIGHLIGHT SURP Day Winners
Page 15 and 16: FEATURE The prostate is a walnut-s
Page 17 and 18: FEATURE analysis suggested a small
Page 19 and 20: FEATURE Photo courtesy of http://ww
Page 21 and 22: FEATURE T ADC DCE MRI - K ep map Fi
Page 23 and 24: FEATURE Pick Your Brain... A column
Page 25 and 26: FEATURE I n line with this hope, it
Page 27 and 28: SPOTLIGHT itself as a versatile and
Page 29 and 30: CLOSE UP Dr. Jill Cameron many of t
Page 31 and 32: SURP RESEARCH FOCUS Given the rigou
Page 33 and 34: VIEWPOINT I think about the ablest
Page 35 and 36: VIEWPOINT this bias should be of hi
Page 37 and 38: BEHIND THE SCENES Most students kno
Page 39 and 40: FUTURE DIRECTIONS terest in genetic
Page 41 and 42: Ask Experts the Dear Experts, Last
Page 43 and 44: DIVERSIONS SUDOKU 2 7 1 5 8 4 9 6 2

Fall 2011 - Institute of Medical Science - University of Toronto

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