INMUNOINFORMATICA - CNB - Protein Design Group
INMUNOINFORMATICA - CNB - Protein Design Group
INMUNOINFORMATICA - CNB - Protein Design Group
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TCR-PMHC FIT AND SELF TOLERANCE OF T-CELLS IS<br />
ADQUIRED DURING THYMIC SELECTION<br />
Thymocyte selection is mediated by<br />
peptide/MHC/TCR interactions<br />
1. 2. 3.<br />
APC<br />
APC<br />
APC<br />
MHC<br />
Ø<br />
+++<br />
+<br />
Interact.<br />
TCR<br />
T<br />
T<br />
T<br />
Nature Reviews Immunology 4; 278-289 (2004);<br />
Death<br />
Neglect<br />
Death<br />
– selection<br />
Survival<br />
+ selection