INMUNOINFORMATICA - CNB - Protein Design Group
INMUNOINFORMATICA - CNB - Protein Design Group
INMUNOINFORMATICA - CNB - Protein Design Group
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Prediction of T cell epitopes<br />
➩ T cell epitopes are peptides derived from the processing of proteins that<br />
are able to activate T cells in a detectable manner<br />
APC<br />
Mechanisms that needs to be modeled<br />
• Antigen processing. Whether a peptide is<br />
processed (released) from a protein in vivo<br />
• Binding of the peptide to the MHC<br />
molecule<br />
• Recognition of the peptide-MHC by the<br />
TCR with enough affinity.<br />
MHC<br />
P<br />
P<br />
TCR<br />
T CELL<br />
MHC-p-TCR
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