Genetic susceptibility to adverse drug effects - Epidemiology ...
Genetic susceptibility to adverse drug effects - Epidemiology ...
Genetic susceptibility to adverse drug effects - Epidemiology ...
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Effect of ABCB1 and NOS1AP genotypes on cardiac function in digoxin users<br />
Table 2 Echocardiographic characteristics<br />
Echocardiographic parameter<br />
NOS1AP ABCB1 Digoxin users<br />
genotyped genotyped<br />
Number 4827 2753 59<br />
Structural parameters<br />
Left ventricular end sys<strong>to</strong>lic dimension, 31.0 (28.0-35.0) 32.0 (28.0-35.0) 34.0 (28.0-43.0)<br />
mm (median (IQR))<br />
Left ventricular end dias<strong>to</strong>lic dimension, 51.2 (5.6) 50.6 (5.9) 53.1 (8.5)<br />
mm (mean (SD))<br />
Sys<strong>to</strong>lic parameters<br />
Ejection fraction, % (median (IQR)) 78.0 (71.3-82.1) 73.7 (68.6-80.6) 71.1 (61.3-78.9)<br />
Fractional shortening, % (mean (SD)) 38.5 (7.1) 36.9 (7.5) 33.2 (10.1)<br />
Left ventricular function, % a<br />
Normal 56.1 44.8 25.9<br />
Fair 38.1 47.9 43.1<br />
Moderate 4.1 5.1 19.0<br />
Poor 1.7 2.3 12.1<br />
Dias<strong>to</strong>lic parameters<br />
Mitral valve inflow peak E, m/s<br />
0.65 (0.16) 0.64 (0.17) 0.68 (0.23)<br />
(mean (SD))<br />
Mitral valve inflow peak A, m/s<br />
0.77 (0.18) 0.78 (0.18) 0.75 (0.20)<br />
(mean (SD))<br />
E/A ratio (median (IQR)) 0.83 (0.71-1.00) 0.80 (0.67-1.00) 0.75 ( (0.65-<br />
1.00)<br />
Mitral valve inflow deceleration time, 215.3 (47.9) 219.3 (51.3) 223.5 (66.7)<br />
msec (mean (SD))<br />
Dias<strong>to</strong>lic function, % b<br />
Normal 51.3 45.0 35.4<br />
Impaired relaxation 12.2 15.1 14.6<br />
Restrictive 0.5 0.5 2.1<br />
Indeterminate 36.0 39.4 47.9<br />
The group of NOS1AP genotyped consists of all genotyped subjects from both the baseline and the extension cohort,<br />
the ABCB1 group comprises only genotyped participants from the baseline cohort, the digoxin group consists of all<br />
genotyped digoxin users from both cohorts. For normally distributed variables, mean (SD) is displayed. If a variable<br />
was not normally distributed, median (inter quartile range (IQR)) is shown.<br />
a Qualitative assessment of ventricular sys<strong>to</strong>lic function<br />
b Normal dias<strong>to</strong>lic function: E/A ratio between 0.75 and 1.50 and deceleration time between 150 ms and 240 ms,<br />
impaired relaxation: E/A ratio < 0.75 and deceleration time > 240 ms, restrictive dias<strong>to</strong>lic dysfunction: E/A ratio > 1.50<br />
and deceleration time < 150 ms.<br />
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