Genetic susceptibility to adverse drug effects - Epidemiology ...

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Genetic Susceptibility to Adverse Drug Effects Common variants in the ABCB1 and NOS1AP genes Genetische gevoeligheid voor bijwerkingen van geneesmiddelen Veelvoorkomende varianten van de ABCB1 en NOS1AP genen Proefschrift ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de rector magnificus Prof.dr. S.W.J. Lamberts en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op woensdag 9 april 2008 om 15.45 uur door Adrianus Leendert Hubertus Jan Aarnoudse geboren te Dordrecht
Promotiecommissie Promotoren: Prof.dr. B.H.Ch. Stricker Prof.dr. A. Hofman Overige leden: Prof.dr. A.G. Uitterlinden Prof.dr. J.C.M. Witteman Prof.dr. L.J.L.M. Jordaens Copromotor: Dr. J.P. Dieleman
Page 1 and 2: Genetic susceptibility to adverse d
Page 3: The work presented in this thesis w
Page 10: 1 General Introduction
Page 13 and 14: Chapter 1 genome. Every SNP represe
Page 15 and 16: Chapter 1 References 1. 2. 3. 4. 5.
Page 18: 2 Quantifying the risk of adverse d
Page 21 and 22: Chapter 2 Introduction The cardiac
Page 23 and 24: Chapter 2 Table 1 Characteristics o
Page 25 and 26: Chapter 2 digoxin treatment appears
Page 27 and 28: Chapter 2 References 1. 2. 3. 4. 5.
Page 30: 3 Common variants in the ABCB1 gene
Page 33 and 34: Chapter 3.1 Introduction The ATP-Bi
Page 35 and 36: Chapter 3.1 Co-variables. Covariate
Page 37 and 38: Chapter 3.1 Table 3 Frequencies of
Page 39 and 40: Chapter 3.1 Table 5 Risk of serum d
Page 41 and 42: Chapter 3.1 Table 6 Other studies o
Page 43 and 44: Chapter 3.1 References 1. 2. 3. 4.
Page 46 and 47: 3.2 Common ABCB1 variants increase
Page 48 and 49: Common ABCB1 variants increase QTc
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Common ABCB1 variants increase QTc
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Chapter 3.3 Introduction The quinol
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Chapter 3.3 In addition to the diar
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Chapter 3.3 Table 1 General charact
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Chapter 3.3 confounding by contrain
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Chapter 3.3 adverse effects of mefl
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Chapter 3.3 References 1. 2. 3. 4.
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4 Common variants in the NOS1AP gen
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Chapter 4.1 Introduction Sudden car
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Chapter 4.1 Assessment of QTc inter
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Chapter 4.1 Table 1 Baseline charac
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Chapter 4.1 Table 3 Number of indiv
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Chapter 4.1 ditional GG haplotype c
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4.2 Common NOS1AP variants potentia
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Common NOS1AP variants potentiate d
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Chapter 4.3 Introduction In the pas
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Chapter 4.3 Figure 1 Flowdiagram of
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Chapter 4.3 Table 1 Characteristics
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Chapter 4.3 Table 2 Cardiovascular
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Chapter 4.3 Table 3 Drugs, NOS1AP a
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Chapter 4.3 found indication that t
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4.4 Common variation in the NOS1AP
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Common variants in the NOS1AP gene
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5 Effect of ABCB1 and NOS1AP genoty
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Effect of ABCB1 and NOS1AP genotype
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6 General discussion Despite all re
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General discussion ening properties
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General discussion or the excess [C
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General discussion continuously mon
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General discussion cardiovascular d
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General discussion for non-cardiova
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General discussion 25. 26. 27. 28.
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General discussion QTc interval in
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General discussion 169
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7.1 Summary Despite all research ef
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Summary reduced mortality in patien
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Chapter 7.2 steeds aanzienlijk is e
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8 Dankwoord Een proefschrift schrij
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Dankwoord Bijzondere dank aan alle
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10 Bibliography Manuscripts based o
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Bibliography Van der Hooft CS, Diel
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