BIOGRAPHICAL SKETCH Michel DRANCOURT Professor of ...

Advantages Brought on by Implementing the e-Management within ... 133Source: the economic-financial document at the companyFigure 1. The evolution of the company (2009-2010)Approximately two years ago, the S.M.E.’s management decided to makesubstantial investments in assets that were to get into use at the beginning of 2010, afact that would involve a triplication of the company’s incomes, this aspect beingpossible due to the results of the company’s economic and financial status analysis thatshowed favourable circumstances.At the same time, the S.M.E. managed to contract business partners, leaders onthe cereals market in U.S.A. with the most difficult to meet requirements. Thebeginning of the economic crisis phenomenon at a time of “big investments”,practically leaving the company without liquidities, made it impossible for thecompany to develop its activities in profitable conditions; therefore, most of theeconomic agents, knowing its situation, were not optimistic with regard to the S.M.E.’schances to redress in the immediately following period. The challenge for the S.M.E. isin finding redressing solutions and solutions for satisfying their American partners.Analyzing the research made by the S.M.E.’s personnel evidenced the fact that theS.M.E. is incapable pose a threat on the market, considering the fact that thecompetition is twice faster with regards to the relationship with clients and 10 timesmore profitable. In this context, the S.M.E. wants to find the fastest way to redressitself economically and to be able to honour the engagement towards its businesspartners, thus being able to get back to the leader position it held previously on themarket.Taking into consideration the present status of the company and the fact that itbelong to a category of companies with a simple organizational structure that can bemodelled fast to the new requirements of the business environment, the solution ofdevelopment by using the virtual environment has been chosen, this involving thecreation of a virtual company which implicitly attracts the adaptation of the company’smanagement system to the new “virtual” reality and the transformation of themanagement science into what may be called e-Management.Practically in this time of speed, on a dynamic and more and more “virtual”market, the S.M.E.’s managers must manoeuvre the digital universe in order to obtain acompetitive advantage. The economic and technological arguments support the

Principal Investigator/Program Director (Last, First, Middle) :72. Drancourt M, Raoult D. Characterization of mutations in the rpoB gene in naturally rifampin-resistantRickettsia species. Antimicrob Agents Chemother. 1999 ;43:2400-3.73. Beau F, Bollet C, Coton T, Garnotel E, Drancourt M. Molecular identification of a Nocardiopsis dassonvilleiblood isolate. J Clin Microbiol. 1999 ;37:3366-8.74. Ridoux O, Drancourt M. Lack of in vitro antimicrosporidian activity of thalidomide. Antimicrob AgentsChemother. 1999 ;43:2305-6.75. Chamorey E, Forel M, Drancourt M. An in-vitro evaluation of the activity of chlorine against environmentaland nosocomial isolates of Aeromonas hydrophila. J Hosp Infect. 1999 ;41:45-9.76. Ridoux O, Drancourt M. In vitro susceptibilities of the microsporidia Encephalitozoon cuniculi,Encephalitozoon hellem, and Encephalitozoon intestinalis to albendazole and its sulfoxide and sulfonemetabolites. Antimicrob Agents Chemother. 1998 ;42:3301-3.77. Stein A, Bataille JF, Drancourt M, Curvale G, Argenson JN, Groulier P, Raoult D. Ambulatory treatment ofmultidrug-resistant Staphylococcus-infected orthopedic implants with high-dose oral co-trimoxazole(trimethoprim-sulfamethoxazole). Antimicrob Agents Chemother. 1998 ;42:3086-91.78. Jacomo V, Musso D, Gevaudan MJ, Drancourt M. Isolation of blood-borne Mycobacterium avium by usingthe nonradioactive BACTEC 9000 MB system and comparison with a solid-culture system. J Clin Microbiol.1998 ;36:3703-6.79. Drancourt M, Aboudharam G, Signoli M, Dutour O, Raoult D. Detection of 400-year-old Yersinia pestisDNA in human dental pulp: an approach to the diagnosis of ancient septicemia. Proc Natl Acad Sci U S A.1998 ;95:12637-40.80. Ridoux O, Foucault C, Drancourt M. Purification of Encephalitozoon cultures contaminated bymycoplasmas by murine intraperitoneal inoculation. J Clin Microbiol. 1998 ;36:2380-2.81. Papazian L, Thomas P, Bregeon F, Garbe L, Zandotti C, Saux P, Gaillat F, Drancourt M, Auffray JP,Gouin F. Open-lung biopsy in patients with acute respiratory distress syndrome. Anesthesiology. 1998;88:935-44.82. Mollet C, Drancourt M, Raoult D. Determination of Coxiella burnetii rpoB sequence and its use forphylogenetic analysis. Gene. 1998 ;207:97-103.83. Mollet C, Drancourt M, Raoult D. rpoB sequence analysis as a novel basis for bacterial identification. MolMicrobiol. 1997 ;26:1005-11.84. Drancourt M, Brouqui P, Raoult D. Afipia clevelandensis antibodies and cross-reactivity with Brucella spp.and Yersinia enterocolitica O:9. Clin Diagn Lab Immunol. 1997 ;4:748-52.85. Drancourt M, Argenson JN, Tissot Dupont H, Aubaniac JM, Raoult D. Psoriasis is a risk factor for hipprosthesisinfection. Eur J Epidemiol. 1997 ;13:205-7.86. Drancourt M, Stein A, Argenson JN, Roiron R, Groulier P, Raoult D. Oral treatment of Staphylococcusspp. infected orthopaedic implants with fusidic acid or ofloxacin in combination with rifampicin. J AntimicrobChemother. 1997 ;39:235-40.87. Drancourt M, Pelletier J, Cherif AA, Raoult D. Gordona terrae central nervous system infection in animmunocompetent patient. J Clin Microbiol. 1997 ;35:379-82.PHS 398/2590 (Rev. 09/04) Page Continuation Format Page

Principal Investigator/Program Director (Last, First, Middle) :103. Musso D, Drancourt M, Bardot J, Legre R. Human infection due to the CDC group IVc-2 bacterium:case report and review. Clin Infect Dis. 1994 ;18:482-4.104. Drancourt M, Raoult D. Taxonomic position of the rickettsiae: current knowledge. FEMS Microbiol Rev.1994 ;13:13-24.105. George F, Brouqui P, Boffa MC, Mutin M, Drancourt M, Brisson C, Raoult D, Sampol J. Demonstrationof Rickettsia conorii-induced endothelial injury in vivo by measuring circulating endothelial cells,thrombomodulin, and von Willebrand factor in patients with Mediterranean spotted fever. Blood. 1993;82:2109-16.106. Drancourt M, Raoult D. Proposed tests for the routine identification of Rochalimaea species. Eur J ClinMicrobiol Infect Dis. 1993 ;12:710-3.107. Drancourt M, Stein A, Argenson JN, Zannier A, Curvale G, Raoult D. Oral rifampin plus ofloxacin fortreatment of Staphylococcus-infected orthopedic implants. Antimicrob Agents Chemother. 1993 ;37:1214-8.108. Brouqui P, Dupont HT, Drancourt M, Berland Y, Etienne J, Leport C, Goldstein F, Massip P, Micoud M,Bertrand A, et al. Chronic Q fever. Ninety-two cases from France, including 27 cases without endocarditis.Arch Intern Med. 1993 ;153:642-8.109. Raoult D, Dupont HT, Chicheportiche C, Peter O, Gilot B, Drancourt M. Mediterranean spotted fever inMarseille, France: correlation between prevalence of hospitalized patients, seroepidemiology, andprevalence of infected ticks in three different areas. Am J Trop Med Hyg. 1993 Feb;48(2):249-56.110. Drancourt M, Oules O, Bouche V, Peloux Y. Two cases of Actinomyces pyogenes infection in humans.Eur J Clin Microbiol Infect Dis. 1993 ;12:55-7.111. Roux V, Drancourt M, Raoult D. Determination of genome sizes of Rickettsia spp. within the spottedfever group, using pulsed-field gel electrophoresis. J Bacteriol. 1992 ;174:7455-7.112. Drancourt M, George F, Brouqui P, Sampol J, Raoult D. Diagnosis of Mediterranean spotted fever byindirect immunofluorescence of Rickettsia conorii in circulating endothelial cells isolated with monoclonalantibody-coated immunomagnetic beads. J Infect Dis. 1992 ;166:660-3.113. Drancourt M, Donnet A, Pelletier J, Raoult D. Acute meningoencephalitis associated withseroconversion to "Afipia felis". Lancet. 1992 ;340:558.114. Drancourt M, Beati L, Tarasevich I, Raoult D. Astrakhan fever rickettsia is identical to Israel tick typhusrickettsia, a genotype of the Rickettsia conorii complex. J Infect Dis. 1992 ;165:1167-8.115. Raoult D, Tissot Dupont H, Caraco P, Brouqui P, Drancourt M, Charrel C. Mediterranean spotted feverin Marseille: descriptive epidemiology and the influence of climatic factors. Eur J Epidemiol. 1992 ;8:192-7.116. Drancourt M, Bonnet E, Gallais H, Peloux Y, Raoult D. Rhodococcus equi infection in patients withAIDS. J Infect. 1992 ;24:123-31.117. Brouqui P, Dupont HT, Drancourt M, Bourgeade A, Raoult D. Spotless boutonneuse fever. Clin InfectDis. 1992 ;14:114-6.118. Drancourt M, Kelly PJ, Regnery R, Raoult D. Identification of spotted fever group rickettsiae usingpolymerase chain reaction and restriction-endonuclease length polymorphism analysis. Acta Virol. 1992;36:1-6.PHS 398/2590 (Rev. 09/04) Page Continuation Format Page