16 researchresearchThe MBL is one of the largest and most excitingbiological laboratories in the world.Offering a stimulating and highly collaborativeenvironment, the MBL attracts many of the world’s topscientists and is a place synonymous with biologicaldiscovery.Currently, 39 Ph.D. level investigators and their staffconduct year-round research that is leading to a betterunderstanding of our climate and planet, our ancestry,the diversity of life on Earth, fisheries and resourcemanagement, as well as global infectious diseases andother serious medical conditions.Every summer, this population swells dramatically,when hundreds of distinguished scientists gather atthe MBL’s Whitman Center for Summer and VisitingResearch and when the faculty and students arrive forour signature summer science courses and workshops.During a typical MBL summer, researchers unlock thesecrets of life by studying simple marine organisms,such as squid, clams, zebrafish, and skates. Theyexplore how nerve cells communicate, how cellsperform complex jobs, and how they proliferate. Theystudy how organisms reproduce and develop, how theyfight disease, how sense organs gather information, andhow brains learn and remember. And they raise andanswer groundbreaking new questions that can helplead to life-saving answers.
esearch 17DIRECTORMitchell L. SoginSENIOR SCIENTISTSStephen L. HajdukDavid J. PattersonMonica RileyMitchell L. SoginASSOCIATE SCIENTISTSRobert M. GreenbergJennifer WernegreenASSISTANT SCIENTISTSAndrew McArthurRobert SabatiniASSOCIATE RESEARCH SCIENTISTHilary G. MorrisonASSISTANT RESEARCH SCIENTISTSLinda Amaral ZettlerSeth BordensteinDavid Mark WelchMargrethe SerresADJUNCT SCIENTISTSIrina Arkhipova, Harvard <strong>University</strong>Matthew Meselson, Harvard <strong>University</strong>Roger Milkman, <strong>University</strong> of IowaWilliam Reznikoff, <strong>University</strong> of WisconsinHarold Zakon, <strong>University</strong> of TexasVISITING SCIENTISTRobert Campbell, Serono ReproductiveBiology InstitutePOSTDOCTORAL SCIENTISTSVerena BrandJoe ConsiglioAshita DhillonDaniel GoldenHeather M. H. GoldstoneContinuedjosephine bay paul center for comparativemolecular biology and evolutionInvestigators in the Josephine Bay Paul Center for Comparative MolecularBiology and Evolution seek to understand the molecular basis and origin ofdisease mechanisms, the evolution of microbial communities, and the influenceof single-cell organisms on planetary processes. They study microbes fromall three domains of life (Archaea, Bacteria, and Eukarya), their evolutionaryhistory, their interactions with each other and macroscopic forms of life, andhow members of diverse microbial communities contribute and respond toenvironmental change. The Josephine Bay Paul Center’s interlocking programsin Global Infectious Diseases, Molecular Evolution, and Molecular MicrobialDiversity foster a special environment that rarely, if ever, occurs in medicalcenters or university departments. Linkages between these biological disciplineshave far-reaching implications for identifying and one day predicting originsand dispersal mechanisms of pathogenecity, and the development of systemslevelapproaches to environmental microbiology.The center fosters many collaborative research initiatives including a molecularecology component of the Long-Term Ecological Research project (MitchellSogin’s laboratory and John Hobbie of The Ecosystems Center); phylogeneticand physiologic studies of acidophilic protists in collaboration with Peter Smithof the BioCurrents Research Center; and studies of molecular diversity amongmarine protists and bacteria (with marine microbiologists at the Woods HoleOceanographic Institution).The Josephine Bay Paul Center supports all of these efforts through itsoperation of state-of-the-art facilities for high-throughput DNA sequencing,DNA microarraying, and large-scale computational facilities within the W.M.Keck Ecological and Evolutionary Genetics Facility. The National Institutesof Health provides major funding to investigate molecular processes andresistance to African trypanosomes, which cause human sleeping sickness,gene expression studies in the human parasites Giardia, Trypanosoma, andSchistosoma, the influence of endosymbiotic relationships on bacterial genomeevolution, the relationships between diverse eukaryotic genera through genomewidecomparisons of expressed genes, and marine-related studies of humandisease through the Woods Hole Center for Oceans and Human Health. TheNational Science Foundation provides support for molecular evolution studiesof endosymbionts, development of digital resources for describing microbialdiversity, and molecular evolution studies of rotifer and microsporidial
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