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View/Open - HPS Repository - Arizona State University

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48 researchlaboratory of norman wainwrightThe mission of this laboratory isto understand the molecular defensemechanisms exhibited by marineinvertebrates in response to invasionby bacteria, fungi, and viruses. Theirprimitive immune systems demonstrateunique and powerful strategies forsurvival in diverse marine environments.The key model has been the horseshoecrab, Limulus polyphemus. Limulushemocytes exhibit a very sensitive LPStriggeredprotease cascade that resultsin blood coagulation. Several proteinsfound in the hemocyte and hemolymphdisplay microbial binding propertiesthat contribute to antimicrobialdefense. Limulus amebocyte lysate (LAL)is being adapted for use as a tool toassess bioburden on spacecraft and tosearch for microbial life in the universe.Collaborations with several NASA centersare actively developing technology in thefield of astrobiology.SENIOR SCIENTISTNorman WainwrightRESEARCH ASSISTANTSAlice ChildKendra WilliamsVISITING INVESTIGATORDan Burbank

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