Fitting Michaelis-Menten directly to substrate concentration data

Direct fit to (S, t) data: S(t) numeric solution?◮ E.g., S(t) by Euler’s method:◮ Note, the slope at t isv(t) = − V maxS(t)K m + S(t)◮ Estimate S(t +h) ≃ S(t) + v(t) × h◮ Start with initial value, S(0)◮ Iterate, gives ˜S(t) for t = 0, h, 2h, ...