Fitting Michaelis-Menten directly to substrate concentration data
Fitting Michaelis-Menten directly to substrate concentration data
Fitting Michaelis-Menten directly to substrate concentration data
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Semi-parametric method?Represent S(t) by f (t) = Φ(t)β,RequireMinimizen∑{s i − f (t i )} 2 + λi=1f ′ (t) ≃ V maxf (t)K m + f (t) .n∑i=1e.g. beta spline{f ′ (t i ) − V }maxf (t i ) 2K m + f (t i )