Genome Mapping Professor Simon G. Gregory
Genome Mapping Professor Simon G. Gregory
Genome Mapping Professor Simon G. Gregory
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<strong>Genome</strong> <strong>Mapping</strong><strong>Professor</strong> <strong>Simon</strong> G. <strong>Gregory</strong>TimeGene 1Homology, orthology, paralogyOriginalfunctionmaintainedGeneSpeciationOrthologuesFunctionalorthologuesDuplicationParaloguesOriginalfunctionmaintainedParaloguesGene 2 Gene 3Novelfunction• HomologuesGenes derived fromcommon ancestral gene• OrthologuesGenes in different speciesthat are derived fromthe same gene in lastcommon ancestor• ParaloguesGene families that havediverged within a singlespecies, often by duplication40Comparative mapping - mouseclone by cloneBACsAve. size 200 kbmapWGSsequenceassemblysequenceassemblypUCs41Physical mapping strategyBACfingerprinting(Marra et al., 1997)305,000 ClonesDnMitBAC libraries(Osoegawa et al., 2000)379,000 Clones BAC endsequencing(Zhao et al., 2001)410,000 BESHuman chromosome 1(<strong>Gregory</strong> et al., 2005)42The screen versions of these slides have full details of copyright and acknowledgements14
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