diabetic neuropathy?1 How DoesMetanx® Work

What causesdiabetic neuropathy? 1How diabetes leads to nerve damage is a subject of intenseresearch, but two main factors are likely involved:A. Elevated blood sugar levels damage theblood vessels and reduce blood flow tothe nerves, starving them of the oxygenand nutrients they need to survive.B. Elevated blood sugar levels directlydamage the nerves resulting in reducednerve fiber density.To learn more visitwww.metanx.comHow Does Metanx ® Workin Diabetic Neuropathy?If you have diabetic neuropathy, there is a good chance thatyou have reduced blood flow to the nerves in your handsand feet. As a result, your nerves may become damagedand lose the ability to repair themselves.Metanx ® provides the nutritionalrequirements needed by diabetespatients to restore the metabolicprocesses associated with diabeticneuropathy to do the following: 3-5C. Maintain blood flow in the vesselsthat carry the nutrients and oxygento your nerves.D. Provide the required nutrients tohelp facilitate nerve repair.A. Reduced Blood FlowC. Restored Blood FlowB. Reduced Nerve Fiber DensityThe majority of diabetes patientswith symptomatic neuropathyhave reduced nerve fibers. 2 = Nerve FiberD. Increased Nerve Fiber DensityNutritional management with Metanx ® has beenshown to increase nerve fibers in patients withdiabetic neuropathy. 4,6Metanx ® is a medical food dispensed by prescription (Rx) for the clinical dietary management of endothelial dysfunction in patients with diabetic peripheral neuropathy. Use under medical supervision.

Why was I prescribed METANX ® ?Metanx ® is a medical food designed forpatients with diabetic neuropathy.Prescribed by healthcare providers,Metanx ® gives your body the needednutrients to improve blood flowand repair damaged nerves. 3-4,6While other treatments for diabeticneuropathy may relieve symptomsfor a short time, Metanx ® worksto address the cause of theseprogressive symptoms. 4How do I take Metanx ® ?You must be under a healthcareprovider’s care to take Metanx ® . Theusual dose is 1 capsule taken twiceeach day. Your healthcare providermay have you take a different dose.Always follow your healthcare provider’srecommendation. 8What are possible side effectsof Metanx ® ?The side effects of Metanx ® are about the same as those of aplacebo. 7 A placebo is a pill or liquid with no active medicine.A sugar pill is an example of a placebo. In rare cases, Metanx ®may cause mild stomach upset or rash. 8How do I know if Metanx ®is working?If you already have nerve damage,it may take some time before younotice that Metanx ® is working. Onaverage people notice that Metanx ® isworking within about 3 weeks. 2 Basedon medical studies, people shouldtake Metanx ® for at least 6 monthsto have significant improvement. 2,7Every person will respond differentlyto Metanx ® .DPN TOTAL SYMPTOMSWays to Fill Your Metanx ® PrescriptionAs with other medications, you can fill your Metanx ® prescription at most retail or online pharmacies.You can also order Metanx ® through a pharmacy called Brand Direct Health. This pharmacy guaranteesa low price, easy ordering, and flexible payments. Here is how to order from Brand Direct Health:Ask your healthcare provider to fax or e-prescribe your prescription to Brand Direct Health.Their fax number is 866-227-5928.Brand Direct Health will then contact you for payment and shipping information.Brand Direct Health ships all orders within 24 hours.Brand Direct Health will contact you again when it is time to refill your prescription.References:1. Vinik, Aaron. The Am Journ of Med 1999;107(2B):17S-26S. 2.Walker M, et al. Rev Neurol Dis 2010;7(4):132-139. 3.Abstractsof the 7th Annual Conference Arteriosclerosis, Thrombosis, and Vascular Biology. Oral Presentations. Arterioscler Thromb Vasc Biol2006;26:e43-e52. 4.Jacobs AM and Cheng D. Rev Neurol Dis 2011;8(1/2):39-47. 5.Watanabe T, et al. J Neurol Sci 1994;122:140-143. 6.Obrosova IG, et al. Diabetes 2012;61:2126-2133. 7.Fonseca V, et al. The Am Journ of Med 2013;126(2):141-149.Item 970-017