Cancer: A Brief Overview

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Appearance of Chromosome RegionsContaining Amplified DNAFrom L. J. Kleinsmith, Principles of <strong>Cancer</strong> Biology. Copyright (c) 2006 Pearson Benjamin Cummings.
1. Growth Factors as Oncoproteins• Only cause TRANSFORMATION whenexpressed in cells expressing the relevant receptor• eg epidermal growth factor EGFExamples of Growth Factor Oncoproteins• Fibroblast Growth Factor• Epidermal Growth Factor (+ TGF?)• Platelet-derived growth factor PDGF• Chemokines• Cytokines eg growth hormone
Page 1 and 2: Cancer: A Brief OverviewLauren Goll
Page 3 and 4: Chromosomal abnormalities in a canc
Page 5 and 6: 2. Inherited cancer syndromesSame t
Page 7 and 8: Classical point of viewOncogenesTum
Page 9 and 10: Natural diversity of tumorsTumors d
Page 11 and 12: RATES of molecular events in cancer
Page 13 and 14: MULTISTEP CARCINOGENESIS1) Initiati
Page 15 and 16: Mechanism of action of phorbol este
Page 17 and 18: Overview of CarcinogenesisFrom L. J
Page 19 and 20: Tumor suppressor genesHave beentheo
Page 21 and 22: Familial retinoblastomahttp://www.d
Page 23 and 24: Role of p53 protein in responding t
Page 25 and 26: Prevalence of p53 mutations in Huma
Page 27 and 28: Role of Ubiquitin in Targeting Prot
Page 29 and 30: Inherited conditions that increaser
Page 31 and 32: ONCOGENES
Page 33: Mechanisms for converting proto-onc
Page 37 and 38: 3. Signal Transduction Components a
Page 39 and 40: 4. Transcription Factors as Oncopro
Page 42 and 43: Experiments on oncogenecooperationS
Page 44 and 45: Ras and Myc can cooperatebecause th
Page 46 and 47: What is Bcl-2’s Normal Role?• F
Page 48 and 49: COMMON TYPESOF MUTATIONS in human c
Page 50 and 51: CARCINOGENIC MUTATIONS,MOST OFTEN R
Page 52 and 53: ANEUPLOIDYLoss or additionof a chro
Page 54 and 55: Chromosome Stabilization• Intact
Page 56 and 57: End-replication problem - Hayflick
Page 58 and 59: Telomerase extension5’3’5’3
Page 60 and 61: What Is Telomerase?TEP1 may facilit
Page 62: What is the minimal tumor cell?Mini

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