Cancer: A Brief Overview

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ANEUPLOIDYLoss or additionof a chromosomeor chromosomematerial.Aneuploidy alters the dosages and expressionof thousands of normal genes(most of them are bystanders, not a cause of cancer)
TelomeresNorton et al, 1997• Chromosomal ends• Repeating base pairsequence– TTAGGG• Holds no geneticinformation• Set length at birth– Most cell lines
Page 1 and 2: Cancer: A Brief OverviewLauren Goll
Page 3 and 4: Chromosomal abnormalities in a canc
Page 5 and 6: 2. Inherited cancer syndromesSame t
Page 7 and 8: Classical point of viewOncogenesTum
Page 9 and 10: Natural diversity of tumorsTumors d
Page 11 and 12: RATES of molecular events in cancer
Page 13 and 14: MULTISTEP CARCINOGENESIS1) Initiati
Page 15 and 16: Mechanism of action of phorbol este
Page 17 and 18: Overview of CarcinogenesisFrom L. J
Page 19 and 20: Tumor suppressor genesHave beentheo
Page 21 and 22: Familial retinoblastomahttp://www.d
Page 23 and 24: Role of p53 protein in responding t
Page 25 and 26: Prevalence of p53 mutations in Huma
Page 27 and 28: Role of Ubiquitin in Targeting Prot
Page 29 and 30: Inherited conditions that increaser
Page 31 and 32: ONCOGENES
Page 33 and 34: Mechanisms for converting proto-onc
Page 35 and 36: 1. Growth Factors as Oncoproteins
Page 37 and 38: 3. Signal Transduction Components a
Page 39 and 40: 4. Transcription Factors as Oncopro
Page 42 and 43: Experiments on oncogenecooperationS
Page 44 and 45: Ras and Myc can cooperatebecause th
Page 46 and 47: What is Bcl-2’s Normal Role?• F
Page 48 and 49: COMMON TYPESOF MUTATIONS in human c
Page 50 and 51: CARCINOGENIC MUTATIONS,MOST OFTEN R
Page 54 and 55: Chromosome Stabilization• Intact
Page 56 and 57: End-replication problem - Hayflick
Page 58 and 59: Telomerase extension5’3’5’3
Page 60 and 61: What Is Telomerase?TEP1 may facilit
Page 62: What is the minimal tumor cell?Mini

Cancer: A Brief Overview

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