Lipid nanocapsules: a tool for improving - AAPS

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First PK Study with PTX-LNCS. Peltier et al., Pharm. Res.,23 (2006) 1243-1250pswc2010
Conclusions of the PK study‣ C max and AUC were increased threefold‣ F was enhanced from 6.5% to 20% in the LNC group‣ 6/8 rats reached the PTX therapeutic level in the LNC groupvs 2/6 in the reference group (Taxol®): sufficient amounts ofPTX were given with this <strong>for</strong>mulation‣ P-gp inhibition by the LNCs‣ The LNCs increase PTX absoption but do not solve the interindividual variabilitypswc2010
Page 6 and 7: WaterOilConductivityPhase Inversion
Page 8 and 9: Routes of administrationPulmonaryro
Page 12 and 13: Development strategy of an oralLNC
Page 14 and 15: Methodology used with Caco-2 cells
Page 16 and 17: Mechanistic studypswc2010 E.Roger e
Page 18 and 19: PTX-LNCs : where are we ?‣ Enhanc
Page 20 and 21: Sn38-LNC‣ Poorly soluble anticanc
Page 22 and 23: Permeability across Caco-2 cellsFre
Page 24 and 25: Nano-encapsulation of Sn 38‣ Sn 3
Page 26 and 27: Perspectives‣ Assessment on cell
Page 28 and 29: LNC transport through the Caco-2 mo

Lipid nanocapsules: a tool for improving - AAPS

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