Lipid nanocapsules: a tool for improving - AAPS

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Methodology used with Caco-2 cells‣ Determination of intracellular and basal PTXby LC-MS/MS‣ Nile red encapsulation <strong>for</strong> intracellularvisualisation by confocal microscopy &quantification by FACS‣ Transport experiments at 4°C or 37°C‣ TEER determination <strong>for</strong> tight junction openingtesting‣ Inhibitions of different receptor-mediatedendocytosis pathwayspswc2010
Uptake and permeability studies1- Nile red LNCMerged2- PTX-loaded LNCE.Roger et al., J Contr Rel, 140 (2009) 174-181pswc2010
Page 6 and 7: WaterOilConductivityPhase Inversion
Page 8 and 9: Routes of administrationPulmonaryro
Page 10 and 11: First PK Study with PTX-LNCS. Pelti
Page 12 and 13: Development strategy of an oralLNC
Page 16 and 17: Mechanistic studypswc2010 E.Roger e
Page 18 and 19: PTX-LNCs : where are we ?‣ Enhanc
Page 20 and 21: Sn38-LNC‣ Poorly soluble anticanc
Page 22 and 23: Permeability across Caco-2 cellsFre
Page 24 and 25: Nano-encapsulation of Sn 38‣ Sn 3
Page 26 and 27: Perspectives‣ Assessment on cell
Page 28 and 29: LNC transport through the Caco-2 mo

Lipid nanocapsules: a tool for improving - AAPS

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