Lipid nanocapsules: a tool for improving - AAPS

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Nano-encapsulation of Sn 38‣ Sn 38-loaded lipid nanocapsules:‣ Stability in gastro-intestinal fluids‣ Enhancement of transepithelial transport‣ Similar cytotoxicity to free Sn 38‣ Ongoing PK studiespswc2010
Lipid nanocapsules : a goodformulation candidate for the oralroute‣ Adjustable size between 20 to 130 nm‣ Stability in simulated media‣ Permeability enhancement demonstrated fordifferent drugs‣ Absolute bioavailability enhancement‣ Proof of concept showed with PTXpswc2010
Page 6 and 7: WaterOilConductivityPhase Inversion
Page 8 and 9: Routes of administrationPulmonaryro
Page 10 and 11: First PK Study with PTX-LNCS. Pelti
Page 12 and 13: Development strategy of an oralLNC
Page 14 and 15: Methodology used with Caco-2 cells
Page 16 and 17: Mechanistic studypswc2010 E.Roger e
Page 18 and 19: PTX-LNCs : where are we ?‣ Enhanc
Page 20 and 21: Sn38-LNC‣ Poorly soluble anticanc
Page 22 and 23: Permeability across Caco-2 cellsFre
Page 26 and 27: Perspectives‣ Assessment on cell
Page 28 and 29: LNC transport through the Caco-2 mo

Lipid nanocapsules: a tool for improving - AAPS

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