Lipid nanocapsules: a tool for improving - AAPS

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PTX-LNCs : where are we ?‣ Enhancement of permeability and bioavailability bya factor 3 after nano-encapsulation of PTX‣ Passive diffusion and energy-dependent transport‣ Several endocytosis pathways‣ No transport in lymph or via the paracellular route‣ Interaction with P-gp‣ Intracellular processing remains undefinedpswc2010
Development strategy of an oralLNC formulation‣ Proof of concept with a PK study with PTX-LNC‣ Set-up of specific evaluation tools for absorptionmechanism study:‣ Single Pass Intestinal Perfusion‣ Stability in biomimetic media‣ Caco-2 cell monolayers‣ Encapsulation of other drug candidates : Ibuprofen,Sn38,…pswc2010
Page 6 and 7: WaterOilConductivityPhase Inversion
Page 8 and 9: Routes of administrationPulmonaryro
Page 10 and 11: First PK Study with PTX-LNCS. Pelti
Page 12 and 13: Development strategy of an oralLNC
Page 14 and 15: Methodology used with Caco-2 cells
Page 16 and 17: Mechanistic studypswc2010 E.Roger e
Page 20 and 21: Sn38-LNC‣ Poorly soluble anticanc
Page 22 and 23: Permeability across Caco-2 cellsFre
Page 24 and 25: Nano-encapsulation of Sn 38‣ Sn 3
Page 26 and 27: Perspectives‣ Assessment on cell
Page 28 and 29: LNC transport through the Caco-2 mo

Lipid nanocapsules: a tool for improving - AAPS

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