Lipid nanocapsules: a tool for improving - AAPS

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WaterOilConductivityPhase Inversion Temperature (PIT)Soft energy methodO/WA.I.PIZW/OTemperature Easy Fast Not expansive Solvent-free No heavy equipmentpswc2010 PatentMicroemulsionLNC
Encapsulation of lipophilic drugs‣ Amiodarone (S = 2 µg/mL)‣ Vitamins A, E,…‣ Ibuprofen (S = 56 µg/mL)‣ Antiseptic agents: chlorhexidine,…‣ Anticancer drugs‣ Etoposide (S = 0.25 µg/mL)‣ Paclitaxel (S = 0.25 µg/mL)‣ Docetaxel (S = 6-7 µg/mL)‣ Derivatives of Camptothecin, Sn38‣ BCNU‣ Derivatives of 4-hydroxy Tamoxifen,…‣ DNA and RNA lipid complexes‣ But, also hydrophilic drugs by playing with <strong>for</strong>mulation variablespswc2010
Page 8 and 9: Routes of administrationPulmonaryro
Page 10 and 11: First PK Study with PTX-LNCS. Pelti
Page 12 and 13: Development strategy of an oralLNC
Page 14 and 15: Methodology used with Caco-2 cells
Page 16 and 17: Mechanistic studypswc2010 E.Roger e
Page 18 and 19: PTX-LNCs : where are we ?‣ Enhanc
Page 20 and 21: Sn38-LNC‣ Poorly soluble anticanc
Page 22 and 23: Permeability across Caco-2 cellsFre
Page 24 and 25: Nano-encapsulation of Sn 38‣ Sn 3
Page 26 and 27: Perspectives‣ Assessment on cell
Page 28 and 29: LNC transport through the Caco-2 mo

Lipid nanocapsules: a tool for improving - AAPS

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