Part II - BEBAC ⢠Consultancy Services for Bioequivalence
Part II - BEBAC ⢠Consultancy Services for Bioequivalence
Part II - BEBAC ⢠Consultancy Services for Bioequivalence
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6/6 | Statistical Design and Analysis <strong>II</strong>IAlgebra…Calculation of CV intra from CI Example: 90% CI [0.91 – 1.15], N 21 (n 1 = 11, n 2 = 10)PE = 0.91⋅ 1.15 = 1.023∆ = ln1.15 − ln1.023 = 0.11702CLMSECV⎛⎞⎜⎟0.11702= 2⎜⎟ = 0.04798⎜ ⎛ 1 1 ⎞ ⎟⎜ ⎜ + ⎟ × 1.729 ⎟⎝ ⎝11 10 ⎠ ⎠0.04798intra% = 100 × e − 1 = 22.2%2in<strong>for</strong>malife sciences<strong>Bioequivalence</strong> and Bioavailability, Pre-Conference Workshop | Ljubljana, 17 May 201014 • 68