Part II - BEBAC â¢ Consultancy Services for Bioequivalence

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6/6 | Statistical Design and Analysis IIIToolsSpecialized Software (nQuery Advisor, PASS,FARTSSIE, StudySize, …)General purpose (SAS, R, S+, StaTable, …)Sample Size Tables (Phillips, Diletti, Hauschke,Chow, Julious, …)Approximations (Diletti, Chow, Julious, …)informalife sciencesBioequivalence and Bioavailability, Pre-Conference Workshop | Ljubljana, 17 May 201026 • 68
6/6 | Statistical Design and Analysis IIIBackgroundReminder: Sample Size is not directlyobtained; only powerSolution given by DB Owen (1965) as adifference of two bivariate noncentral t-distributionsDefinite integrals cannot be solved in closed form‘Exact’ methods rely on numerical methods (currentlythe most advanced is AS 243 of RV Lenth;implemented in R, FARTSSIE, EFG). nQuery uses anearlier version (AS 184).informalife sciencesBioequivalence and Bioavailability, Pre-Conference Workshop | Ljubljana, 17 May 201027 • 68
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Part II - BEBAC â¢ Consultancy Services for Bioequivalence

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Part II - BEBAC â¢ Consultancy Services for Bioequivalence