Part II - BEBAC • Consultancy Services for Bioequivalence

6/6 | Statistical Design and Analysis IIIPooling of CV%Example 3: n 1 >n 2 ;CV Study1 < CV Study2studies N df (total) α 1-α total CV pooled CV mean2 36 32 0.2 0.8 1.7246 0.235 0.245χ² (1-α,df) 25.148 0.266 +13.2%CV intra n seq. df (mj) σ W σ² W σ² W × dfCV intra /pooled>CL upper0.200 24 2 22 0.198 0.0392 0.8629 85.0% no0.300 12 2 10 0.294 0.0862 0.8618 127.5% yesinformalife sciencesBioequivalence and Bioavailability, Pre-Conference Workshop | Ljubljana, 17 May 201022 • 68