Part II - BEBAC • Consultancy Services for Bioequivalence

6/6 | Statistical Design and Analysis IIISensitivity Analysisinformalife sciencesMust be done before the study (a priori)A posteriori power:High values do not support the claim of alreadydemonstrated bioequivalenceLow values do not invalidate a bioequivalentformulationFurther reader:JM Hoenig and DM HeiseyThe Abuse of Power: The Pervasive Fallacy of Power Calculations for Data AnalysisThe American Statistician 55/1, 19–24 (2001)http://www.math.uiowa.edu/~rlenth/Power/2badHabits.pdfRV LenthTwo Sample-Size Practices that I don’t recommendJoint Statistical Meetings, Indianapolis (2000)http://www.math.uiowa.edu/~rlenth/Power/2badHabits.pdfBioequivalence and Bioavailability, Pre-Conference Workshop | Ljubljana, 17 May 201044 • 68