Part II - BEBAC • Consultancy Services for Bioequivalence

6/6 | Statistical Design and Analysis IIIPooling of CV%Example 1: n 1 =n 2 ;CV Study1 < CV Study2studies N df (total) α 1-α total CV pooled CV mean2 24 20 0.2 0.8 1.2540 0.254 0.245χ² (1-α,df) 14.578 0.300 +17.8%CV intra n seq. df (mj) σ W σ² W σ² W × dfCV intra /pooled>CL upper0.200 12 2 10 0.198 0.0392 0.3922 78.6% no0.300 12 2 10 0.294 0.0862 0.8618 117.9% yesinformalife sciencesBioequivalence and Bioavailability, Pre-Conference Workshop | Ljubljana, 17 May 201020 • 68