Part II - BEBAC â¢ Consultancy Services for Bioequivalence

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6/6 | Statistical Design and Analysis IIIPooling of CV%Intra-subject CV from different studies can bepooledDo not use the arithmetic mean (or the geometricmean either) of CVsIn the parametric model of log-transformed data,additivity of variances (not of CVs!) applyBefore pooling variances must be weightedacccording to the sample sizeCalculate the variance from CVσ = ln( CV + 1)2 2Wintrainformalife sciencesBioequivalence and Bioavailability, Pre-Conference Workshop | Ljubljana, 17 May 201018 • 68
6/6 | Statistical Design and Analysis IIIPooling of CV%Intra-subject CV from different studiesCalculate the total variance weighted by degreesof freedom∑σ 2df WCalculate the pooled CV from total variance2CV e σ Wdf df=∑ ∑−1Optionally calculate an upper (1-α) % confidencelimit on the pooled CV (recommended α=0.20)CLCV∑ σ χ − ∑2 2Wdf1 α , df1= e −informalife sciencesBioequivalence and Bioavailability, Pre-Conference Workshop | Ljubljana, 17 May 201019 • 68
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Part II - BEBAC â¢ Consultancy Services for Bioequivalence

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Part II - BEBAC â¢ Consultancy Services for Bioequivalence