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Are COX-2 inhibitors a solution to problems associated with current oral analgesics? A revisit with a perspective of local need.2002 Malstrom et al. 69 Rofecoxib, 50mgCelecoxib, 200 mgCelecoxib, 400 mgIburofen, 400 mgPlacebo2002 Fricke et al. 70 Rofecoxib, 50 mg; followed byplacebo if requested at 4 hoursValdecoxib, 40 mg followed bysecond dose if requested at 4hoursPlacebo; followed by placebo ifrequested at 4 hours2004 Christensen et al. 71 Valdecoxib, 40 mgRofecoxib, 50 mgPlacebo2004 Zelenakas et al. 72 Lumiracoxib, 50 mgLumiracoxib, 100 mgIbuprofen, 400 mgPlacebo2004 Kellstein et al. 73 Lumiracoxib, 400 mgRofecoxib, 50 mgCelecoxib, 200 mgPlacebo2004 Chang et al. 74 Etoricoxib, 120 mgOxycodone, 10mg +paracetamol, 650 mgPlacebo2004 Malstrom et al. 75 Etoricoxib, 120mgNaproxen sodium, 550 mgParacetamol, 600mg + codeine60 mgPlacebo2004 Malstrom et al. 76 Etoricoxib, 60mgEtoricoxib, 120mgEtoricoxib, 180mg Etoricoxib,240 mgIbuprofen, 400 mgPlacebo1.2.3.1.2.1.2.1.2.1.2.1.2.3.1.2.3.1.2.3.4.Time to onset of analgesic effect and peakanalgesic effect were similar for rofecoxib 50mg and celecoxib 400 mg.Celecoxib 200mg inferior to rofecoxib withregard to onset and analgesic effectCelecoxib 400mg is superior to celecoxib 200mg with regard to analgesic effectValdecoxib superior to rofecoxib with regard toonset and analgesic effectValdecoxib exhibited longer duration of action.Valdecoxib superior to rofecoxib with regard toonset and analgesic effect at first 90 minutesAfter that, analgesic effect similar betweenvaldecoxib and rofecoxibLumiracoxib and ibuprofen were equivalentwith regard to onset and analgesic effectLumiracoxib exhibited longer duration of actionLumiracoxib and rofecoxib superior to celecoxibwith regard to onset and analgesic effectLumiracoxib superior to rofecoxib with regardto onsetOxycodone/paracetamol superior to etoricoxibwith regards to onsetEtoricoxib exhibited longer duration of actionthan oxycodone/paracetamolEtoricoxib superior to oxycodone/paracetamolwith regard to analgesic effectEtoricoxib and naproxen sodium were equivalentwith regard to analgesic effect and are superiot toparacetamol/codeineEtoricoxib, naproxen sodium and paracetamol/codeine were equivalent with regard to onsetEtoricoxib and naproxen sodium exhibited longerduration of action than paracetamol/codeineEtoricoxib 120 & 180 mg superior to etoricoxib60 mg and ibuprofen with regard to analgesiceffectEtoricoxib 120, 180 & 240 mg and ibuprofenwere equivalent with regard to onsetEtoricoxib exhibited longer duration of actionthan ibuprofenEtoricoxib 120 mg determined to be the minimumdose that had maximal efficacy.88