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Oral Granular Cell Tumour: A Clinicopathological Study Of 7 Cases And A Brief Review Of The LiteratureCONCLUSIONAlthough oral granular cell tumour is quite anuncommon lesion in the oral cavity, clinicians shouldconsider it in their clinical differential diagnosis of a singlelump when seen clinically especially if the lesion is locatedon the tongue.ACKNOWLEDGEMENTThe authors thank the Director General of HealthMalaysia and also to Director of Institute for MedicalResearch, Kuala Lumpur for their kind permission topublish this paper.REFERENCES1. Harikumar R, Simikumar, Aravindan SK, Thomas V.Abrikossoff’s tumor of the esophagus: case report and reviewof literature. Trop Gastroenterol 2006: 27(1): 52-3.2. Baloch ZW, Martin S, Livolsi VA. Granular cell tumor of thethyroid: a case report. Int J Surg Pathol 2005; 13(3): 291-4.3. Sohn DK, Choi HS, Chang YS, Huh JM, Kim DH, Kim DY etal. Granular cell tumor of colon: report of a case and reviewof literature. World J Gastroenterol 2004; 10(16): 2452-4.4. Eguia A, Uribarri A, Escoda CG, Crovetto MA, Martinez-Conde R, Aguirre JM. Granular cell tumor: report of 8intraoral cases. Med Oral Patol Oral Cir Bucal 2006; 11:E425-8.5. Angiero F, Crippa R, Stefani M. Granular cell tumour in theoral cavity: report of eleven cases treated with laser surgery.Minnerva Stomatol 2006; 55: 423-30.6. Xue JL, Fan MW, Wang SZ, Chen XM, Li Y. Aclinicopathological study of 14 cases of oral granular celltumor. Zhonghua Kou Qiang Xue Za Zhi 2005; 40(4): 302-5.7. Brannon RB, Anand PM. Oral granular cell tumors: an analysisof 10 new pediatric and adolescent cases and a review of theliterature. J Clin Pediatr Dent 2004; 29(1): 69-74.8. Chrysomali E, Nikitakis NG, Tosios K, Sauk JJ, PapinicolaouSI. Immunohistochemical evaluation of cell proliferationantigen Ki-67 and apoptosis-related proteins Bcl-2 andcaspase-3 in oral granular cell tumor. Oral Surg Oral MedOral Pathol Oral Radiol Endod 2003; 96: 566-72.9. Smith JL, Feehery JM, O’Hara BJ, Rao VM, Vernose GV.Granular cell tumor of the parotid: A case report and literaturereview. Ear Nose Throat J 2001; 80: 454-7.10. Boulos R, Marsot-Dupuch K, De Saint-Maur P, Meyer B,Tran Ba Huy P. Granular cell tumor of the palate: a casereport. AJNR Am J Neuroradiol 2002; 23(5): 850-4.11. Worsaae N, Schwartz O, Pindborg JJ. Follow-up study of 14granular cell tumors. Int J Surg 1979; 8(2): 133-9.12. Tosios K, Rallis G, Vallianatou D, Vlachodimiropoulos D.Yellow-white tumor on the floor of the mouth. Oral Surg OralMed Oral Pathol Oral Radiol Endod 2006; 101: 701-04.13. Jones JK, Kuo TT, Griffiths TM, Itharat S. Multiple granularcell tumor. Laryngoscope 1980: 90: 1646-51.14. Enzinger FM, Weiss SW. Soft tissue tumours. 4th ed. Mosby;2001: p. 1178-1187.15. Maiorano E, Favia G, Napoli A, Resta L, Ricco R, Viale G,Altini M. Cellular heterogeneity of granular cell tumours: aclue to their nature? J Oral Pathol Med 2000; 284-90.16. Williams HK, Williams DM. Oral granular cell tumours: ahistological and immunocytochemical study. J Oral PatholMed 1997; 26: 164-9.17. Junquera LM, de Vicente JC, Vega JA, Losa JL, Albertos JM.Granular cell tumours: an immunohistochemical study. Br JOral Maxillofac 1997; 35: 180-84.18. Kaiserling E, Ruck P, Xiao JC. Congenital epulis and granularcell tumor. A histologic and immunohistochemical study. OralSurg Oral Med Oral Pathol Oral Radiol Endod 1995; 80: 687-97.19. Wang J, Zhu XZ, Zhang RY. Malignant granular cell tumor:a clinicopathologic analysis of 10 cases with review ofliterature. Zhonghua Bing Li Xue Za Zhi 2004; 33(6): 497-502.20. Stewart CM, Watson RE, Eversole LR, Werner F, LeiderAS. Oral granular cell tumors: a clinicopathologic andimmunocytochemical study. Oral Surg Oral Med Oral Pathol1988; 65: 427-35.21. Christopherson WM, Foote FW, Stewart FW. Alveolar softpartsarcomas. Structurally characteristic tumors of uncertainhistogenesis. Cancer 1952; 5: 100-111.22. Monteil RA, Loubiere R, Charbit Y, Gillet JY. Gingivalgranular cell tumor of the newborn: Immunoperoxidaseinvestigation with anti-S-100 antiserum. Oral Surg Oral MedOral Pathol 1987; 64: 78-81.23. Fanburg-Smith JC, Meis-Kindblom JM, Fante R, KindblomLG. Malignant granular cell tumour of soft tissues: diagnosticcriteria and clinicopathologic correlation. Am J Surg Pathol1998; 22: 779-94.24. Aksoy S, Abali H, Kilickap S, Harputluoglu H, Erman M.Metastatic granular cell tumor: A case report and review ofthe literature: letter to the editor. Acta Oncologica 2006; 45:91-94.Address for correspondence:Dr. Ajura bt. Abdul Jalil,Stomatology Unit,Institute for Medical Research,50588 Jalan Pahang,Kuala Lumpur96