MCDB 165A - BIOLOGY OF THE CELL SYLLABUS – FALL ... - UCLA

MCDB 165A - BIOLOGY OF THE CELLSYLLABUS – FALL 2008Professor:Luisa Iruela-Arispe, Ph.D.Office Location: 445F Biomedical Research BuildingPhone: 794-5763Email: arispe@mcdb.ucla.eduOffice hours: Fridays 1:00-2:00pmLecture meets: Tuesdays and Thursdays, 11am-12:15pm – Franz Hall 1260TAs: David Chan, Qiming Deng and Krishna ChodavarapuDIS 1A T 1:30pm – 2:20pm Geology 6704 Krishna ChodavarapuDIS 1D W 9:00am – 9:50am Geology 4645 Krishna ChodavarapuDIS 1E W 11:00am – 11:50am Geology 4645 David ChanDIS 1F W 12:00pm – 12:50pm Geology 4645 David ChanDIS 1G R 1:00pm – 1:50pm Geology 6704 Qiming DengDIS 1H R 2:00pm – 2:50pm Geology 6704 Qiming DengTAs Office hours:Krishna Chodavarapu Mondays 12:30pm – 1:30pm BSRB 401David Chan Tuesdays 12:30pm – 1:30pm BSRB501Qiming Deng Wednesdays 2 – 3pm BSRB 501Class website: http://www.lsic.ucla.edu/classesTextbook Required:Molecular Biology of the Cell; Authors: Bruce Alberts, Alexander Johnson, Julian Lewis,Martin Raff, Keith Roberts, Peter Walter5th Edition; Garland ScienceReader – Available at Course Reader Material – 1081 Westwood Blvd., ENTRANCE on Broxtonsouth of Wayburn Phone # (310) 443-3303Course Requirements:6 Reports1 Essay2 Midterms1 Final Exam (cumulative)Grading:Weight for the final grade will be the following:Essay - 10%Reports / Quizzes / Participation - 15%Mid-terms - 40% (20% each)Final - 35%

Mid-term and final exams will consist of a mix of multiple choice questions and shortanswers. They will cover materials from the lectures, readings, and discussion sessions. Thefinal exam will be cumulative. Exams must be written in ink, no pencil allowed.Makeup exams are NOT given. In the case that you are unable to take an examination orhave an illness or emergency, you are responsible for contacting your TA before the examination.A written verification regarding the illness or emergency must be provided. If you feel that amistake in grading has been made on your exam, submit your exam and a typed explanation toyour teaching assistant by Friday (5pm) of the week following the exam. When you submit yourexam for re-grading, the entire content of the exam will be taken into consideration.Written Assignment / EssayA 4-page essay (double-spaced) on a subject related to one of the papers of the discussionsessions. Due November 25th. or earlierFinal ExamThursday, December 11 th- 3-6pmPapers for Discussion Sessions:Paper 1:Nydegger S, Khurana S, Krementsov DN, Foti M, Thali M. Mapping of tetraspanin-enrichedmicrodomains that can function as gateways for HIV-1. J Cell Biol. 2006 Jun 5;173(5):795-807Paper 2:Kakinuma N, Roy BC, Zhu Y, Wang Y, Kiyama R. Kank regulates RhoA-dependent formation of actinstress fibers and cell migration via 14-3-3 in PI3K-Akt signaling. J Cell Biol. 2008 May 5;181(3):537-49.Paper 3:Lampugnani MG, Orsenigo F, Gagliani MC, Tacchetti C, Dejana E. Vascular endothelial cadherin controlsVEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol. 2006 Aug14;174(4):593-604.Paper 4:Pegtel DM, Ellenbroek SI, Mertens AE, van der Kammen RA, de Rooij J, Collard JG. The Par-Tiam1complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity. Curr Biol.2007 Oct 9;17(19):1623-34.Paper 5:Bonnon C, Bel C, Goutebroze L, Maigret B, Girault JA, Faivre-Sarrailh C. PGY repeats and N-glycansgovern the trafficking of paranodin and its selective association with contactin and neurofascin-155.Mol Biol Cell. 2007 Jan;18(1):229-41Paper 6:Bethani I, Lang T, Geumann U, Sieber JJ, Jahn R, Rizzoli SO. The specificity of SNARE pairing inbiological membranes is mediated by both proof-reading and spatial segregation. EMBO J. 2007 Sep5;26(17):3981-92

LECTURE SCHEDULE FOR MCDB-165AWK DATE LECTURE DISCUSSION SESSION0 09/25 Introduction to the Course NONE1 09/30 1. Methods to Study Cells Introduction and10/02 2. Cell Membrane Paper 12 10/07 3. Cell Signaling Paper 210/09 4. Cell-Cell Interactions3 10/14 5. Integrins and Extracellular Matrix I Review for Midterm I10/16 6. Intregrins and Extracellular Matrix II and Session Quiz4 10/21 Midterm I (Lectures 1-5) Paper 310/23 7. Cytoskeleton5 10/28 8. Extracellular Motility and Migration Paper 410/30 9. Intracellular Motility6 11/04 10. Protein Synthesis and End. Reticulum I Review for Midterm II11/06 11. Protein Synthesis and End. Reticulum I and Session Quiz7 11/11 Veterans day holiday Paper 511/13 Midterm II (Lectures 6-11) (W and R sessions only)8 11/18 12. Golgi Complex Paper 5 (T session)11/20 13. Secretion Paper 6(W and R Sessions)9 11/25 14. Proteasomes and Protein turnover Paper 6 (T session)11/27 Thanksgiving Holiday10 12/02 15. Lysosomes and Peroxisomes Review for Final12/04 16. Mitochondria and Apoptosis and Session Quiz