16 intrauterine programming of ncd 24 olson memori... - DSM

SIGHT AND LIFE | VOL. 25 (2) | 2011 VITAMIN D AND INFLAMMATION 4141(Scotland) was similar, 1,13 except that in the more recent studybaseline 25(OH)D values were not restored by Day 5. Mean plasma25(OH)D values remained approximately 25% lower than preoperativevalues at day 5 and were still depressed by this amountat three months post-op. It is probable that the depression of25(OH)D concentrations at three months may have been due tothe nature of the surgery. For patients undergoing replacement ofa knee joint, it is conceivable that mobility remained a problem,whereas the CRP response of the subjects in the South Africanstudy suggested that the severity of the surgery was less. Furthermore,the latitude of the surgical unit in Scotland (55ºN) andthe high rainfall in that area will not have helped the patients toobtain much useful solar radiation throughout much of the year.Reid and colleagues considered what might have contributedto the loss of 25(OH)D from the blood. The possibility that thefall in the binding protein and albumin concentrations may havecontributed to the loss of 25(OH)D was considered, but the fallin protein concentrations was only ~20% while 25(OH)D concentrationsfell by 40%. However, it is interesting to compare thebehavior of 25(OH)D with that of plasma retinol, about whichmore is known. (Table 3) Early changes in epithelial permeabiltable1: Influence of idiopathic osteoporosis on “free” vitamin D metabolitesVitamin D metabolite Osteoporosis n=56Mean ± SDControls n=114Mean ± SDP