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Emerging Markets for Microfluidic Applications - I-Micronews

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<strong>Emerging</strong> <strong>Markets</strong> <strong>for</strong><br />

<strong>Microfluidic</strong> <strong>Applications</strong><br />

(EMMA 2011)<br />

Report Sample<br />

45 rue Sainte Geneviève, F-69006 Lyon, France<br />

Tel : +33 472 83 01 80 - Fax : +33 472 83 01 83<br />

Web: http://www.yole.fr


Table of content<br />

1 – EXECUTIVE SUMMARY<br />

2 – INTRODUCTION<br />

3 – MICROFLUIDICS MARKET 2011-<br />

2016<br />

• Market geographical distribution<br />

• Impact of microfluidics<br />

• <strong>Microfluidic</strong> applications<br />

• <strong>Microfluidic</strong> components market value<br />

and <strong>for</strong>ecast<br />

• Compound Annual Growth Rates<br />

2008-<br />

2010 and 2011-2016<br />

4 – WHAT HAPPENED SINCE 2009?<br />

• <strong>Microfluidic</strong>s, a dynamic market<br />

• <strong>Microfluidic</strong> Patents 2009-2011<br />

• Market data versus EMMA2009<br />

<strong>for</strong>ecasts<br />

© 2011 • 2<br />

5 – MICROFLUIDIC APPLICATIONS<br />

• General Dispensing<br />

• Drug Delivery<br />

• Accurate Dispensing<br />

• Analytical Devices<br />

• Clinical and veterinary diagnostics<br />

• Point Of Care testing<br />

• Industrial and environmental testing<br />

• Pharmaceutical and life science<br />

• Microreaction technology<br />

6 – MICROFLUIDIC TECHNOLOGIES<br />

7 – MICROFLUIDIC SUPPLY CHAIN<br />

8 – MICROFLUIDIC VALUE CHAIN<br />

9 – SUMMARY AND CONCLUSIONS<br />

EMMA 2011 September 2011 Copyrights © Yole Développement SA. All rights reserved.


EMMA 2011: Scope<br />

© 2011 • 3<br />

<strong>Microfluidic</strong>s<br />

Technologies<br />

<strong>Microfluidic</strong>s<br />

<strong>Applications</strong><br />

Market data<br />

& Forecasts<br />

EMMA<br />

2011<br />

<strong>Microfluidic</strong>s<br />

Supply<br />

Chain<br />

What happen<br />

since 2009?<br />

Many device<br />

examples <strong>for</strong><br />

each<br />

application<br />

EMMA 2011 September 2011 Copyrights © Yole Développement SA. All rights reserved.


<strong>Microfluidic</strong>s Component Market<br />

Three assumptions <strong>for</strong> the future<br />

<strong>Microfluidic</strong> Devices market in M$<br />

© 2011 • 4<br />

5000<br />

4500<br />

4000<br />

3500<br />

3000<br />

2500<br />

2000<br />

1500<br />

1000<br />

500<br />

0<br />

<strong>Microfluidic</strong> Devices market in M$<br />

2010 2011 2012 2013 2014 2015 2016<br />

EMMA 2011 September 2011 Copyrights © Yole Développement SA. All rights reserved.<br />

Micro Reaction Technology<br />

Drug delivery (inhalers,<br />

micropumps, microneedles)<br />

Industrial and environmental<br />

Analytical devices<br />

Pharmaceutical and life science<br />

research<br />

Point of Care diagnostics<br />

clinical & veterinary diagnostics<br />

Total <strong>for</strong>ecast<br />

Optimistic Forecast<br />

Pessimistic Forecast


Market data versus EMMA 2009 <strong>for</strong>ecasts<br />

• The graph below shows the microfluidics device market, as predicted in the EMMA<br />

2009 and the actual data obtained from reported sales of the top 150 players.<br />

• <strong>Microfluidic</strong> device market has grown less than predicted in our last report due to<br />

the fact that the segment Point of Care has not taken off as expected.<br />

© 2011 • 5<br />

EMMA 2011 September 2011 Copyrights © Yole Développement SA. All rights reserved.


Market data versus EMMA 2009 <strong>for</strong>ecasts<br />

(M$)<br />

50<br />

45<br />

40<br />

35<br />

30<br />

25<br />

© 2011 • 6<br />

Industrial and environmental<br />

20<br />

2008 2009 2010<br />

Industrial &<br />

environment<br />

applications,<br />

including Energy<br />

- EMMA 2009<br />

Industrial &<br />

environment<br />

applications,<br />

including Energy<br />

- Real<br />

The industrial and environmental segment has<br />

experienced a strong growth<br />

In Yole Developpement opinion this growth can be<br />

explained by the fact that many hidden technologies in<br />

development came on the market and generated sales.<br />

In addition, many technologies originally developed <strong>for</strong><br />

the POC market found an application in the<br />

environmental and agro-food applications.<br />

(M$)<br />

EMMA 2011 September 2011 Copyrights © Yole Développement SA. All rights reserved.<br />

190<br />

170<br />

150<br />

130<br />

Drug Delivery<br />

110<br />

2008 2009 2010<br />

Drug Delivery -<br />

EMMA 2009<br />

Drug Delivery -<br />

Real<br />

<strong>Microfluidic</strong> technologies <strong>for</strong> drug delivery have<br />

experienced a sustained growth with a CAGR<br />

of 21% during the period 2008-2010.<br />

<strong>Microfluidic</strong> technologies seem to be important<br />

tools in order to improve the efficacy and<br />

reduce side effects of the treatment.<br />

The growth observed can be principally<br />

accounted to the market success of the inhaler<br />

technology of Boehringer Ingelheim (Respimat)


<strong>Microfluidic</strong>s technologies & applications<br />

Technologies<br />

Legend:<br />

© 2011 • 7<br />

Dispensing<br />

Micro analysis devices<br />

Chemical & biological<br />

Synthesis<br />

<strong>Applications</strong><br />

Medical<br />

applications<br />

Drug Delivery<br />

Inhalers<br />

Microneedles<br />

Analytical<br />

Device<br />

Dispensing, Spotting<br />

Analyses<br />

= <strong>Microfluidic</strong>s chips<br />

In Vitro Diagnostic applications<br />

Clinical & Veterinary<br />

Diagnostics<br />

Cartridges <strong>for</strong><br />

clinical and<br />

veterinary<br />

diagnostics<br />

Point Of Care<br />

Micropumps, Microvalves<br />

POC<br />

Intensive<br />

care, doctor<br />

office, near<br />

patient,…<br />

Industrial &<br />

Environment<br />

Testing<br />

Identification<br />

of pathogens<br />

(Agro Food,<br />

Water analysis)<br />

EMMA 2011 September 2011 Copyrights © Yole Développement SA. All rights reserved.<br />

Research & Production<br />

applications<br />

Pharmaceutical<br />

research<br />

Dispensing,<br />

Spotting<br />

Genomics<br />

Proteomics<br />

Cell based<br />

assays<br />

Microreaction<br />

Micro Reaction<br />

- Research units<br />

- Pilot production<br />

units


Chips / <strong>Applications</strong> in IVD Diagnosis<br />

Type of detection<br />

on chip<br />

<strong>Applications</strong><br />

© 2011 • 8<br />

Chemicals<br />

detection<br />

Blood gas<br />

analysis<br />

Immunoassays<br />

detection<br />

• Serodiagnostic<br />

• Fast and low<br />

cost Pathogen<br />

detection<br />

(bacteria, virus)<br />

• Pathogen<br />

identification<br />

(strains,<br />

serogroup)<br />

In Vitro Diagnosis<br />

Molecular<br />

detection<br />

• Accurate<br />

pathogen<br />

detection and<br />

identification<br />

• Typing<br />

• Pathogen<br />

quantification<br />

EMMA 2011 September 2011 Copyrights © Yole Développement SA. All rights reserved.<br />

Cytometry<br />

detection<br />

• Complete Blood<br />

Count (CBC)<br />

• Detection and<br />

analysis of<br />

microscopic<br />

particles such<br />

as bacteria and<br />

animal cells


Drug Delivery and Infusion Devices<br />

�µneedels<br />

© 2011 • 9<br />

Boehringer<br />

MicroParts<br />

Respimat®<br />

Wearable Electronic<br />

Disposable Drug delivery<br />

Birch Point Medical Inc.<br />

WEDD<br />

R&D<br />

�Smart Patches<br />

� Needle free injection<br />

Ceramic microneedles<br />

R&D<br />

Commercially<br />

available $<br />

Commercially<br />

available $$$<br />

� Inhalers<br />

Inhalation and<br />

spray delivery<br />

Transdermal<br />

Injection<br />

devices<br />

ZA Medical<br />

Medspray<br />

Active drug<br />

delivery<br />

systems<br />

The Intellidrug tooth implant<br />

EMMA 2011 September 2011 Copyrights © Yole Développement SA. All rights reserved.<br />

Roche - Disetronic<br />

Panomat®<br />

Microdosage pumps<br />

� Infusion pumps<br />

� Implantable pumps<br />

� Smart pills<br />

ChipRx<br />

Commercially<br />

available $$$<br />

R&D<br />

R&D<br />

Debiotech micropump


Materials distribution<br />

2010<br />

© 2011 • 10<br />

EMMA 2011 September 2011 Copyrights © Yole Développement SA. All rights reserved.


Silicon <strong>Microfluidic</strong>s supply chain & players<br />

© 2011 • 11<br />

Design Prototype Volume Integration and distribution<br />

<strong>Microfluidic</strong>s<br />

players<br />

CEA Leti, DTU, IMEC,<br />

FZK,ITRI, VTT, Draper<br />

Lab…<br />

IDMs<br />

STM, Sharp, IBM, NXP, Philips, TEL<br />

MEMS Foundries<br />

Silex, Dalsa, Colibrys, IMT, Lionix, C2V, SVTC, Olivetti…<br />

EMMA 2011 September 2011 Copyrights © Yole Développement SA. All rights reserved.<br />

Integrators<br />

Agilent Biomerieux Veredus<br />

Mobidiag<br />

Life Technology,<br />

Pacific Bioscience<br />

Silicon Biosystems<br />

...


Yole activities in <strong>Microfluidic</strong>s<br />

© 2011 • 12<br />

Media business<br />

News feed / Magazines /<br />

Webcasts<br />

Market<br />

Research<br />

Reports &<br />

database<br />

EMMA 2011 September 2011 Copyrights © Yole Développement SA. All rights reserved.<br />

Consulting<br />

services<br />

Market research,<br />

Technology & Strategy<br />

www.yole.fr


<strong>Microfluidic</strong>s reports from YOLE<br />

© 2011 • 13<br />

EMMA 2011 September 2011 Copyrights © Yole Développement SA. All rights reserved.

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