CMA-Microdialysis.pdf - somapharm.ch

Microdialysis for Advanced UseCathetersCMA 66 Linear Microdialysis Catheterfor use in skin, adipose, and resting skeletal muscle tissue49THE CMA 66 LINEAR MICRODIALYSIS CATHETER is a minimally invasive sterile single use deviceintended for Microdialysis monitoring in skin, adipose or resting skeletal muscle tissue. The catheter isavailable with either 20,000 or 100,000 Daltons cut off membrane. The CMA 66 is suitable for manyresearch applications: metabolic research, estimating the free fraction of a drug, pharmacokinetic andpharmacodynamic studies or monitoring inflammatory processes in vivo.Insertion into the tissue is easily done with the help of a small needle introducer. The unique patentedlinear design makes the catheter robust and safe to use for several days. When using the high cut offmembrane we recommend perfusing the catheter with a fluid containing high molecular weight substancesfor fluid balance and to avoid ultra filtration (e.g. 30g Dextran 60/1000mL).ORDERING INFORMATIONCMA 66 Linear MicrodialysisCatheter 4/pkgRef. No.CMA 66 Linear Catheter30 mm, 20kDincludes Needle introducer 8010650CMA 66 High Cut Off Linear Catheter30 mm, 100kDincludes Needle introducer 8010651CMA 66 Linear Catheter10 mm, 20kDIncludes Needle introducer 8010670CMA 66 High Cut Off Linear Catheter10 mm, 100kDincludes Needle introducer 8010671AccessoriesFor product information on Perfusion Fluid andSyringes, see pg 60-61.3.1.4.2.5.Parts of the CMA 66 Linear MicrodialysisCatheter1. Introducer needle 21 G, 50mm2. Luer-Lock connection3. Outlet tube4. Dialysis membrane5. Inlet tubeTECHNICAL INFORMATIONCAUTION: Investigational DeviceLimited by United States Law to Investigational Use.To be used only for Institutional Review Board (IRB) approved or, if applicable, FDA approved studies.• Available with 20 000 or 100 000 Daltons cut-off• Unique Linear Microdialysis Catheter for clinical useMembrane cut-off: 20 000 Daltons orHigh Cut Off membrane: 100 000 DaltonsMaterial Length Diameter(mm) (mm) (mm)8010650/51 8010670/71Membrane PAES* 30 10 0.5Inlet tubing PUR** 400 400 0.38Outlet tubing PUR** 100 100 0.38* polyarylethersulfone ** polyurethane