Type 2 Diabetes Adult Outpatient Insulin Guidelines - CMA Foundation
Type 2 Diabetes Adult Outpatient Insulin Guidelines - CMA Foundation
Type 2 Diabetes Adult Outpatient Insulin Guidelines - CMA Foundation
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TABLe 20 <strong>Insulin</strong> Injectables<br />
Drug class Generic name brand<br />
name<br />
Rapid-acting Lispro Humalog 5-15 min 30-90<br />
min<br />
Aspart Novolog 5-15 min 30-90<br />
min<br />
Glulisine Apidra 5-15 min 30-90<br />
min<br />
Onset Peak Duration Comments<br />
< 5 hr Clear<br />
< 5 hr<br />
< 5 hr<br />
Short acting Regular (R) Human 30-60 min 2-3 hr 5-8 hr Clear<br />
Intermediate<br />
acting<br />
NPH (N) Human 2-4 hr 4-10 hr 10-16 hr Cloudy<br />
Long acting Detemir Levemir 3-8 hr 3-4 hr<br />
(50%)<br />
No peak<br />
Premixed –<br />
human<br />
6-24 hr,<br />
dose<br />
dependent<br />
Glargine Lantus 2-4 hr No peak 20-24 hr<br />
75% insulin<br />
lispro protamine<br />
suspension/<br />
25% insulin<br />
lispro<br />
50% insulin<br />
lispro protamine<br />
suspension/<br />
50% insulin<br />
lispro<br />
70% insulin<br />
aspart protamine<br />
suspension/ 30%<br />
insulin aspart<br />
70% NPH/ 30%<br />
regular<br />
Humalog<br />
Mix 75/25<br />
Humalog<br />
Mix 50/50<br />
NovoLog<br />
Mix 70/30<br />
70% NPH/<br />
30%<br />
regular<br />
Note: Nausea and vomiting can be lessened or avoided with dose titration.<br />
Clear,<br />
typically<br />
taken once<br />
daily (example<br />
before evening<br />
meals or at<br />
bedtime). Helps<br />
prevent high<br />
morning blood<br />
glucose values.<br />
5-15 min Dual 10-16 hr Cloudy<br />
5-15 min Dual 10-16 hr<br />
5-15 min Dual 10-16 hr<br />
30-60 min Dual 10-16 hr<br />
<strong>CMA</strong> FoundAtion . diAbetes And CArdiovAsCulAr diseAse Provider reFerenCe guide . july 2011 35<br />
Comprehensive<br />
management of<br />
type 2 diabetes
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