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Type 2 Diabetes Adult Outpatient Insulin Guidelines - CMA Foundation

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TAbLe 17 Oral Medications<br />

Drug class Generic name brand name(s) Mechanism of<br />

action<br />

biguanides Metformin Fortamet<br />

Glucophage<br />

Glucophage XR<br />

Glumetza<br />

Riomet<br />

Inhibits liver<br />

glucose<br />

production,<br />

q muscle glucose<br />

uptake<br />

Sulfonylureas Glimepiride Amaryl q pancreatic<br />

insulin<br />

production<br />

Glipizide Glipezide ER<br />

Glipezide XL<br />

Glucotrol<br />

Glucotrol XL<br />

Glyburide Diabeta<br />

Glynase<br />

Micronase<br />

Glycron<br />

Meglitinides Repaglinide Prandin q insulin released<br />

from pancreas<br />

Thiazolidinediones<br />

(TZDs)<br />

Alpha-glucosidase<br />

inhibitors<br />

bile acid<br />

sequestrant<br />

Nateglinide Starlix<br />

Pioglitazone Actos q skeletal muscles<br />

Avandia<br />

glucose uptake<br />

Rosiglitazone**<br />

**Restricted use by<br />

FDA due to possible<br />

increased CV risk<br />

(only use if unable to<br />

use other options.)<br />

Acarbose Precose Inhibits<br />

carbohydrate<br />

absorption by<br />

the small intestine<br />

Colesevelam<br />

hydocloride<br />

Welchol Lipid t polymer<br />

that binds bile<br />

acids in the<br />

intestine, t<br />

reabsorption.<br />

The exact A1c t<br />

action is currently<br />

unknown.<br />

Potential side<br />

effects<br />

Cramping, nausea,<br />

diarrhea, vomiting,<br />

gas, loss of appetite,<br />

metallic taste<br />

Hypoglycemia, GI<br />

upset, weight gain<br />

(note: avoid<br />

glyburide in elderly<br />

and those with renal<br />

insufficiency due<br />

to increased risk of<br />

hypoglycemia in this<br />

population.)<br />

Hypoglycemia,<br />

weight gain, joint<br />

pain<br />

Hypoglycemia,<br />

edema, headache,<br />

mild anemia, weight<br />

gain, muscle pain,<br />

URI, sinusitis<br />

Cramping, diarrhea,<br />

gas, GI upset/pain,<br />

weight loss.<br />

Need to treat<br />

hypoglycemia with<br />

glucose<br />

Constipation,<br />

nasopharyngitis,<br />

dyspepsia,<br />

hypoglycemia,<br />

nausea, hypertension<br />

<strong>CMA</strong> FoundAtion . diAbetes And CArdiovAsCulAr diseAse Provider reFerenCe guide . july 2011 27<br />

Comprehensive<br />

management of<br />

type 2 diabetes

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