Type 2 Diabetes Adult Outpatient Insulin Guidelines - CMA Foundation
Type 2 Diabetes Adult Outpatient Insulin Guidelines - CMA Foundation
Type 2 Diabetes Adult Outpatient Insulin Guidelines - CMA Foundation
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TAbLe 17 Oral Medications<br />
Drug class Generic name brand name(s) Mechanism of<br />
action<br />
biguanides Metformin Fortamet<br />
Glucophage<br />
Glucophage XR<br />
Glumetza<br />
Riomet<br />
Inhibits liver<br />
glucose<br />
production,<br />
q muscle glucose<br />
uptake<br />
Sulfonylureas Glimepiride Amaryl q pancreatic<br />
insulin<br />
production<br />
Glipizide Glipezide ER<br />
Glipezide XL<br />
Glucotrol<br />
Glucotrol XL<br />
Glyburide Diabeta<br />
Glynase<br />
Micronase<br />
Glycron<br />
Meglitinides Repaglinide Prandin q insulin released<br />
from pancreas<br />
Thiazolidinediones<br />
(TZDs)<br />
Alpha-glucosidase<br />
inhibitors<br />
bile acid<br />
sequestrant<br />
Nateglinide Starlix<br />
Pioglitazone Actos q skeletal muscles<br />
Avandia<br />
glucose uptake<br />
Rosiglitazone**<br />
**Restricted use by<br />
FDA due to possible<br />
increased CV risk<br />
(only use if unable to<br />
use other options.)<br />
Acarbose Precose Inhibits<br />
carbohydrate<br />
absorption by<br />
the small intestine<br />
Colesevelam<br />
hydocloride<br />
Welchol Lipid t polymer<br />
that binds bile<br />
acids in the<br />
intestine, t<br />
reabsorption.<br />
The exact A1c t<br />
action is currently<br />
unknown.<br />
Potential side<br />
effects<br />
Cramping, nausea,<br />
diarrhea, vomiting,<br />
gas, loss of appetite,<br />
metallic taste<br />
Hypoglycemia, GI<br />
upset, weight gain<br />
(note: avoid<br />
glyburide in elderly<br />
and those with renal<br />
insufficiency due<br />
to increased risk of<br />
hypoglycemia in this<br />
population.)<br />
Hypoglycemia,<br />
weight gain, joint<br />
pain<br />
Hypoglycemia,<br />
edema, headache,<br />
mild anemia, weight<br />
gain, muscle pain,<br />
URI, sinusitis<br />
Cramping, diarrhea,<br />
gas, GI upset/pain,<br />
weight loss.<br />
Need to treat<br />
hypoglycemia with<br />
glucose<br />
Constipation,<br />
nasopharyngitis,<br />
dyspepsia,<br />
hypoglycemia,<br />
nausea, hypertension<br />
<strong>CMA</strong> FoundAtion . diAbetes And CArdiovAsCulAr diseAse Provider reFerenCe guide . july 2011 27<br />
Comprehensive<br />
management of<br />
type 2 diabetes