F R I D A Y • A P R I L - Pediatric Academic Societies

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8:00 Brainstem Processing Disorders Sanjiv B. Amin, University of Rochester, Rochester, NY 8:20 Auditory Processing Disorders Steven M. Shapiro, Medical College of Virginia, Richmond, VA 8:40 Panel Discussion: Lessons Learned and Yet to be Learned David K. Stevenson, Stanford University School of Medicine, Stanford, CA Lucile Salter Packard Children’s Hospital at Stanford, Palo Alto, CA 8:00am–10:00am 1100A Acute Para-infectious Neurologic Disorders ASPR Symposium~Korbel 4A Target Audience: Pediatricians and pediatric neurologists who treat children with convulsion and/or coma. Objective: - To provide participants with practical knowledge on the classification, diagnosis and treatment of acute encephalitis and encephalopathy, as well as interest in the vigorous research activity in this field Chairs: Masashi Mizuguchi, The University of Tokyo, Tokyo, Japan and Derek Neilson, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH Acute encephalitis and encephalopathy are the most serious complications of pediatric viral infections, such as influenza and exanthem subitum. Recently, new syndromes of acute encephalitis and encephalopathy have been established, and their pathogenetic mechanism has been elucidated. New methods of diagnosis and treatment have been introduced. Genetic background has been identified for some syndromes. This session deals with the cutting edge of clinical, laboratory, radiologic and genetic studies on acute encephalitis and encephalopathy. 8:00 The Genetics of Acute Necrotizing Encephalopathy: RANBP2 and Beyond Derek Edmund Neilson, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 8:25 Acute Encephalopathy: Pathogenesis and Genetic Background Masashi Mizuguchi, The University of Tokyo, Tokyo, Japan 8:50 Serum Cytochrome C Is a Good Marker for Estimating Apoptosis in Acute Child Diseases. Hiroyuki Nunoi, Tomoyuki Mizukami, Akihiko Yuge, Migumi Obara. Publication 1100A.1 9:05 Which Is the Most Effective Guide To Control Hypoxic/Ischemic Insult in a Newborn Piglet Model? Cerebral Electrocortical Activity Versus Cerebral Blood Volume. Shinji Nakamura, Kosuke Koyano, Masaaki Ueno, Takanori Miki, Makoto Nakamura, Sonoko Ijichi, Saneyuki Yasuda, Kensuke Okubo, Takashi Kusaka, Kenichi Isobe, Susumu Itoh. Publication 1100A.2 9:20* Joint Effects of Hypoxic-Ischemic and Infectious Events on the Risk of Cerebral Palsy in Very-Low-Birth-Weight Preterm Infants: A Population Cohort Study. Lan-Wan Wang, Chao-Ching Huang, Shan-Tair Wang. Publication 1100A.3 ASPR Best Research Award Shinya Hirano 9:35 Better Developmental Function at 3 Years for Infants Born at 22-23wks Who Participated in the Randomized Controlled Trial for the Prevention of Intraventricular Hemorrhage by Indomethacin in Japanese Extremely Low Birthweight Infants. Shinya Hirano, Masanori Fujimura. Publication 1100A.4 ASPR Best Research Award Yi Qu 9:50 TERT Induction in Hypoxia-Ischemia Developing Rat Brain Attenuates Astrogliosis and Promotes Neuronal Survival. Yi Qu, Dezhi Mu, Zhoujin Duan, Fengyan Zhao, Jianbo Zhang. Publication 1100A.5 Sponsored by the Asian Society for Pediatric Research *First Author is Trainee (fellow, house officer or student) Daily Programming 8:00am–10:00am 1105 Advances in Pediatric Hepatobiliary and Pancreatic Disease PAS Topic Symposium~Korbel 2C Target Audience: Scientists and clinicians practicing general pediatrics, adolescent medicine, immunology, gastroenterology, endocrinology, genetics and nutrition. Objective: - Understand the mechanisms of injury in autoimmune liver and pancreatic disease, evalutate children and adolescents at risk for NAFLD and review injury causing mechanisms, discuss disease specific diagnosis and pathology in metabolic liver disease Chairs: William F. Balistreri, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH and Judith O’Connor, University of Arkansas, Arkansas Children’s Hospital, Little Rock, AR Liver disease in children results from many causes that include infectious, inflammatory, metabolic, and drug and toxin induced. Metabolic causes can result from a single gene defect or as a genetic susceptibility induced by a trigger such a drug or a metabolic derangement associated with visceral obesity (Nonalcoholic Fatty Liver Disease/NAFALD). Taken individually single gene defects are rare but account for up to 10% of pediatric liver transplantations. NAFALD and associated NASH (Nonalcoholic steatohepatitis) is a world wide problem of childhood and is the most common cause of liver disease in the age group. Inflammatory disorders such as autoimmune hepatitis, sclerosing cholangitis and autoimmune pancreatitis are chronic disorders resulting from immune dysregulation. This course will review and discuss mechanisms of liver injury, diagnosis and treatment of common causes of liver disease in children and adolescents. 8:00 Progress in Liver Disease of Childhood William F. Balistreri, Cincinnati Children’s Hosptial Medical Center, Cincinnati, OH 8:05 Crossreactivity in Autoimmune Diseases of the Liver, Bile Ducts and Pancreas: AIH/PSC & PSC/Autoimmune Pancreatitis Michael R. Narkewicz, University of Colorado Denver School of Medicine/The Children’s Hospital, Aurora, CO 8:40 Understanding Genetic and Nutritional Risks for the Development of NAFLD/NASH Saul J. Karpen, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX 9:15 Metabolic Liver Disease in Childhood Ronald J. Sokol, University of Colorado, The Children’s Hospital, Aurora, CO 9:50 Discussion Jointly sponsored by the North American Society for Pediatric Gastroenterology, Hepatology & Nutrition and the Pediatric Academic Societies 8:00am–10:00am 1110 Hypoxic Respiratory Failure in the Term and Near Term Infant PAS Topic Symposium~Four Seasons 1 Target Audience: Clinicians and researchers interested in learning more about advances in the pathophysiology and management of hypoxic respiratory failure in the newborn. Objective: - Understand application of new diagnostic and therapeutic tools in the management of hypoxic respiratory failure in term and near term infants Chairs: Sessions Cole, Washington University School of Medicine, St. Louis Children’s Hospital, St. Louis, MO and Lucky Jain, Emory University and Children’s Healthcare of Atlanta, Atlanta, GA This state of the art session will bring together leading clinician scientists and lung biology experts to discuss advances in the management of hypoxic www.pas-meeting.org S A T U R D A Y • A P R I L 0
S A T U R D A Y • A P R I L 0 Daily Programming respiratory failure. Respiratory distress after birth impacts a large number of term and near term neonates worldwide and is a significant contributor to morbidity and mortality given its large etiologic fraction. Our understanding of the pathophysiology has improved in recent years, and with it our ability to target therapies. In this symposium, we will begin with a broad overview of epidemiologic data, highlighting risk factors associated with HRF. Genetic studies are beginning to reveal hitherto unknown causes of intractable HRF and these will be highlighted. Finally, advances in managing HRF will be discussed with particular emphasis on new therapies which have improved outcomes or have the potential for doing so in this population. 8:00 Recent Trends, Morbidity, and Mortality in HRF at Term and Near Term Gestations Lucky Jain, Emory University and Children’s Healthcare of Atlanta, Atlanta, GA 8:20 Genetic Origin and Pathophysiology of Intractable Hypoxic Respiratory Failure: ABCA3 and Beyond F. Sessions Cole, Washington University School of Medicine, St. Louis Children’s Hospital, St. Louis, MO 8:45 Lung Protective Strategies in HRF: Where is the Evidence? Richard A. Polin, Babies & Children’s Hospital, Columbia University, New York, NY 9:10 Hemodynamic Attributes in HRF Satyan Lakshminrusimha, Women and Children’s Hospital of Buffalo, Buffalo, NY 9:35 ECMO: Are We Making Most Use of This Modality? John P. Kinsella, University of Colorado School of Medicine, Aurora, CO 8:00am–10:00am 1115 Metabolic Syndrome / Obesity in the Eastern and Western World PAS Topic Symposium~Korbel 2B/3B Target Audience: General pediatricians, endocrinologists, geneticists, epidemiologists, dieticians, adolescent medicine, cardiologists, scientists and clinicians interested in obesity and metabolic syndrome. Objectives: - To understand differences in presentation of metabolic syndrome and risk for diabetes in children and adolescents in Asian and western countries - To learn the principles of management of metabolic syndrome Chairs: Silva A. Arslanian, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA and Takehiko Ohzeki, Hamamatsu University School of Medicine, Hamamatsu, Japan Metabolic syndrome in association with obesity is one of the most pressing medical topics not only in North America but also in Asian countries. Because obesity in childhood predominantly tracks into adulthood, it should be a key for prevention of obesity/metabolic syndrome and following type 2 diabetes mellitus in adults. In addition to genes related to the function of adipocyte and energy-controlling system, changes in lifestyle in various countries all over the world is one of the most important causes for obesity. Comparison of the metabolic syndrome between areas with different ethnic and cultural backgrounds will show more clearly the pathophysiology. It may be interesting to compare the syndrome in children and adolescents in Western countries, such as USA, with those in Asia, including Japan and Korea. In this symposium, diagnosis, epidemiology, and management of metabolic syndrome and related disorders in the USA and Asian countries are discussed. 8:00 Metabolic Syndrome in Youth in the Western World So Jung Lee, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 8:20 Genetic Backgrounds and Metabolic Syndrome in Obese Children in the Eastern World Keiichi Hanaki, Tottori University School Of Medicine, Yonago, Japan 8:30 Epidemiology and Risk Factors for Metabolic Syndrome Mi Jung Park, Inje University College of Medicine, Seoul, Korea 9:00 Type 2 Diabetes Mellitus and Obesity/Metabolic Syndrome in Children and Adolescents Philip S. Zeitler, The Children’s Hospital, Denver, CO 9:30 Earlier Screening and Management for Metabolic Syndrome in Children and Adolescents: Governmental Projects in Japan Takehiko Ohzeki, Hamamatsu University School of Medicine, Hamamatsu, Japan Jointly sponsored by the Asian Society for Pediatric Research, Pediatric Endocrine Society and the Pediatric Academic Societies 8:00am–10:00am 1120 State of Maintenance of Certification in 2011: Find Out about Your Options! PAS Topic Symposium~Korbel 2A/3A Target Audience: All board certified pediatricians. Objectives: - List the four parts of MOC and the timeline for completion - Describe the educational options available through the AAP to fulfill MOC requirements - Explain how an individual can fulfill MOC Part 4 by participating in one’s specialty society’s or regional QI project Chairs: Theodore C. Sectish, Children’s Hospital Boston, Harvard Medical School, Federation of Pediatric Organizations, Boston, MA and Judith Shaw, University of Vermont, Burlington, VT Board-certified pediatricians are now aware of the new process to maintain certification by the American Board of Pediatrics (ABP), but many are unsure about what to do for their next steps. In an effort to educate and inform PAS attendees, this Topic Symposium will focus on the steps of Maintenance of Certification (MOC), particularly Parts 2 + 4. The 2-hour session will consist of four 20-minute presentations followed by 5 minutes of discussion, and conclude with a summary by panel members. The topic areas include: an overview of the MOC process from the ABP; options to fulfill 2 parts of MOC through the AAP; how participation in a multi-practice subspeciality quality improvement collaborative can help you be a better doctor and improve the care you provide while satisfying an MOC requirement; and how pediatricians within regions may join a QI network and fulfill their requirements for MOC Part 4. 8:00 Welcome and Overview Theodore Sectish, Children’s Hospital Boston, Harvard Medical School, Federation of Pediatric Organizations, Boston, MA 8:05 Overview of MOC from the ABP Paul V. Miles, American Board of Pediatrics, Chapel Hill, NC 8:30 Educational Options for Recertification from the AAP Ramesh C. Sachdeva, Medical College of Wisconsin, Milwaukee, WI 8:55 Subspeciality Quality Improvement Collaborative: MOC is Icing on the Cake Richard B. Colletti, University of Vermont College of Medicine, Burlington, VT 9:20 National Improvement Partnership Network Judith Shaw, University of Vermont, Burlington, VT 9:45 Summary 8:00am–10:00am 1125 The Kidney: Roles as a Culprit and a Bystander in Childhood Cancer PAS Topic Symposium~Korbel 1E/F Target Audience: Pediatric nephrologists, oncologists, intensivists, and generalists. The appeal of this symposium will be that the broad roles of the kidney in cancer will be considered. Objectives: - To provide an up-to-date overview of the kidney in childhood cancer - To discuss primary kidney cancers in childhood cancer, as well as both the role of the kidney in paraneoplastic disorders and and the renal consequences of chemotherapy Chairs: Ann Guillot, University of Vermont College of Medicine and Vermont Children’s Hospital, Burlington, VT and Sangeeta Hingorani, University of Washington and Seattle Children’s Hospital, Seattle, WA
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