here - Molecular Medicine Ireland
here - Molecular Medicine Ireland
here - Molecular Medicine Ireland
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microRNA• Mature microRNAs areBiogenesis:single stranded RNAs~22nt in length• Function in the posttranscriptionalregulationof gene expressionpredominantly throughbase-pairing with the3’UTR of target mRNAcausing• mRNA cleavage anddegradation• Inhibition of proteintranslationSeed region:Bases 2- 8 at the 5’ region of the maturemicroRNA.Level of complementarity in this region willdetermine efficiency of binding to thetarget.