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Individual microRNA as commonmarkers• Certain microRNA already emerging gaspotential common markers• E.g. miR-21• Up-regulated in cancer demonstrated t d in 10independent studies• Breast, brain, lung, colorectal, l pancreatic, prostatetand cervical
microRNA signatures• Already established: s ed• microRNA expression signatures specific tocancer types & subtypes• Signatures predictive of survival• microRNA expression in response totreatment is ongoingg• Future:• Signatures predictive of drug sensitivity andresistance will prove invaluable in theindividual id treatment t t of patientst
Page 1 and 2: Widespread Dysregulation ofMiRNAs i
Page 3 and 4: Impact of microRNA regulation• Sa
Page 5: Advantages of looking at miRNA prof
Page 9 and 10: MiRNAs Differentially Expressed inN
Page 13 and 14: A miRNA expressionprofile associate
Page 15 and 16: Result: miRNA expression signature
Page 17 and 18: Stratification of 11q− tumors bas
Page 19 and 20: Conclusion• Our work identifies a

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