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Summary Treatment produced about a 20% reductionin IOP. Treatment reduced incidence of POAG in OHTparticipants by more than 50% at 5 years from9.5% in the Observation Group to 4.4 % in theMedication Group. Little evidence of safety concerns.June, 2002
Significant Baseline Predictive Factorsfrom Univariate Proportional Hazards ModelsAge DecadeHazard Ratio (95% CI)1.43 (1.19, 1.71)African American origin1.59 (1.09, 2.32)Male gender1.87 (1.31, 2.67)Diabetes Mellitus0.40 (0.18, 0.92)Heart Disease2.11 (1.23, 3.62)IOP per mm Hg1.11 (1.04, 1.18)CCT per 40 microns decrease1.88 (1.55, 2.29)PSD per 0.2 dB increaseHorizontal C/D Ratio per 0.1 increase1.36 (1.16, 1.60)1.25 (1.14, 1.38)June, 2002Vertical C/D Ratioper 0.1 increase0 1 2 3 4 51.32 (1.19, 1.46)
Page 1 and 2: The Ocular HypertensionTreatment St
Page 3 and 4: Why did we do this study?Don’t we
Page 5 and 6: Ocular Hypertension Treatment Study
Page 7 and 8: Patient found eligible for OHTS•
Page 9 and 10: Baseline Characteristics by Randomi
Page 15 and 16: IOP By RaceMedicationObservationAfr
Page 17 and 18: Progress and Outcome of Study Parti
Page 19 and 20: Proportion POAG1 st Visual Field PO
Page 21 and 22: First POAG Endpoint per Participant
Page 23 and 24: Treatment perhaps less protectivein
Page 25 and 26: Percent Reporting Changes inIris, L
Page 27: Borderline Safety DifferencesBetwee
Page 31 and 32: Significant Baseline Predictive Fac
Page 33 and 34: POAG Endpoints by Central Corneal T
Page 35 and 36: 60-year-old WF IOP 24 / 24 C/D rati
Page 37 and 38: 60-year-old WF IOP 28 / 28 C/D rati
Page 39 and 40: 72-year-old BM IOP 25 / 25 C/D rati
Page 41 and 42: Weaknesses1. Convenience sample rat
Page 43 and 44: Possible Misinterpretations of OHTS
Page 45: OHTS Clinical CentersBascom Palmer

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