COORDINATORDr Manfred WeidmannBereich Humanmedizin der Georg-AugustUniversität GöttingenStiftung des Öffentlichen RechtsDe<strong>part</strong>ment of VirologyAm Kreuzbergring 5737075 GöttingenGermanyE-mail: mweidma@gwdg.deTel. (49-5513) 89 94 06Fax (49-5513) 89 94 39CONTRACTORSDr Jean-Claude ManugerraInstitut PasteurCellule d’intervention biologique d’urgence25, rue du Dr Roux75724 ParisFranceE-mail: imanugu@pasteur.frTel. (33) 676 16 04 76Fax (33) 140 61 38 07Dr Ali MirazimiSwedish Institute for Infectious Disease ControlCenter for microbiological preparednessNobelv 18SolnaSwedenE-mail: ali.mirazimi@smi.ki.seTel. (46-8) 457 25 73Fax (46-8) 30 79 57Dr Amadou Alpha SallInstitut Pasteur de DakarArbovirus Unit36, avenue Pasteur, B.P. 220DakarSenegalE-mail: asall@pasteur.snTel. (221) 839 92 23Fax (221) 839 92 10Dr Laurent ToeMulti Disease Surveillance centre, World HealthOrganization, African RegionLaboratoire de biologie moléculaire1473, avenue Naba Zombré, 01 B.P. 549OuagadougouBurkina FasoE-mail: toel@oncho.oms.bfTel. (226) 50 34 38 18Fax (226) 50 34 36 75Dr Youssouf IssabreFondation Mérieux MaliLaboratoire Rodolphe MérieuxRue du Docteur Charles Mérieux, Ex-baseaérienne, B.P. E22 83BamakoMaliE-mail:youssouf.issabre@fondationmerieux-mali.orgTel. (223) 636 75 25Fax (223) 22 51 55Dr Lamine KoivoguiUniversité de Conakry, Faculté de médecineInstitut de microbiologieCentre hospitalier universitaire Donka5680 ConakryGuineaE-mail: koivogui@biasy.netTel. (224-4) 340 84 01Fax (224-4) 679 93Dr Klaus-Ingmar PfrepperMikrogen-molekularbiologischeEntwicklungsgesellschaft mbHFloriansbogen 2-482061 NeuriedGermanyE-mail: pfrepper@mikrogen.deTel. (49-895) 480 11 91Fax (49-895) 480 11 00Developing Countries
A multidisciplinary alliance to optimize schistosomiasis control and transmission surveillancein sub-Saharan AfricaPeriod: 01/10/2006 to 30/09/2010Budget from EC: EUR 2 900 000Coordinator: Dr Thomas K. KristensenInstitute for Health Research and Development (DBL)CONTRAST is a multidisciplinary research alliance focusedupon technological innovation and provision of newknowledge to develop locally-adapted and sustainableintervention strategies, complementary with morbiditycontrol using praziquantel (PZQ). CONTRAST is committedto creating a new and much-needed platform for integratedschistosomiasis control in Africa, which will be effective andsustainable at national and local level.CONTRAST is a multidisciplinary alliance bringing togetherkey skills and expertise to generate new knowledge onbiological, environmental, and socio-economic factorsrelating to schistosomiasis in sub-Saharan Africa. The projectwill complement ongoing chemotherapy campaigns basedon the drug praziquantel and deliver more effective strategiesfor long-term control of this debilitating disease. The projectaddresses the basic need of endemic countries to improveunderstanding of schistosomiasis transmission, in order totarget, and make best use of limited resources for control.CONTRAST will lead to better local control solutions thatare more sustainable. Working with five European <strong>part</strong>ners(established research institutes and a representative fromthe commercial sector), a strong research node networkacross sub-Saharan Africa will do the following: establishinnovative molecular tools to characterise both snailsand schistosomes; define the importance of host-parasitedynamics across different ecological and epidemiologicalsettings; develop new spatial models for disease risk mapsand prediction; encourage and assess novel local controlinterventions using a social science approach; and ensurewidespread dispersal and access to information.A realistic contribution to solving problems will be achievedby placing a greater emphasis on integrated strategiesappropriate to the specific, local settings necessary to caterto the focality and spatial heterogeneity of schistosomiasis.The benefits will be to identify the key biological,environmental, demographic, and socio-economic factorsthat maintain schistosomiasis at high levels of endemicity.As such integrated control strategies provide additionalevaluation indicators upon which success or failure can betested, these will include: relationship across endemic areas for diseasetransmission models; variation within snails and schistosomes from typicaldisease endemic environments, enabling associatedchanges following chemotherapy selective pressure tobe assessed; contamination in the environment through the use ofnovel molecular detection methods; spatial epidemiological models that aim to predict thedistribution of schistosomiasis at local levels; with clean water and adequate sanitation and its localeffects upon schistosomiasis transmission; schistosomiasis control through the use of interrogativequestionnaire methods.Dissemination of knowledge will be to identify targetgroups, specifically the international scientific and medicalcommunities, as well as all health care stakeholdersworking with communicable tropical diseases in sub-Saharan Africa. Contribution to health policy standardswill be made through representation of <strong>part</strong>ners at thefollowing organisations: the World Health Assembly Forumand WHO technical Expertise Groups, international medicaland scientific conferences on international health, as wellas at other key stakeholders meeting who have accessto basket funds to provide health or associated services(e.g. Global Initiatives). Partners with CONTRAST will alsoliaise at national governmental level, providing advice onschistosomiasis control, and environmental quality andmanagement, including governmental authorities andNGOs working within these sectors. In addition, <strong>part</strong>nerswill engage with the general public in endemic areas atselected field sites.Health and public health