Biosynthesis of Nucleotides Biosynthesis of Nucleotides - Ecu

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NO=CNH 2CCHNCHGlutamineGlutamateCytidylateSynthetase*Allostericallyinhibited by CTPCytidine 5’-Triphosphate (CTP)
Mammalian pyrimidine synthesis is anexample <strong>of</strong> metabolite channeling.In bacteria, the six enzymes <strong>of</strong> de novo pyrimidinesynthesis are separate proteins.In mammals, the six activities are contained withinthree proteins.CPS-II, asparate transcarbamoylase, dihydroorotaseare all contained within a single cytosolic protein.DHO d’hase is localized in the inner mito.membrane. Orotate phosphoribosyltransferase andOMP decarboxylase are contained with a singleprotein called OMP synthase.
Page 1 and 2: Biosynthesis ofNucleotides
Page 3 and 4: Two Pathways for NucleotideBiosynth
Page 5 and 6: Origin of ring atoms of purines:CO
Page 7 and 8: Phosphoribosylpyrophosphate (PRPP)
Page 9 and 10: O=CNH 2CH 2 NHCHO
Page 11 and 12: H 2 NHCCNNCH
Page 13 and 14: COO-OHC-NHCH 2COO-CH 2 NCCNNCH
Page 15 and 16: OH 2 NCO=CH-NHCCNNCH
Page 17 and 18: - OOC-CH 2-CH-COO -HNHCOCNIMPCCNNCH
Page 19 and 20: OHNHCOCNIMPCCNNCHNADHNAD + IMP D’
Page 21 and 22: Regulation of Purine Biosynthesis:
Page 23 and 24: AMPPPiAdeninephosphoribosyltransfer
Page 25 and 26: Lesch-Nyhan Syndrome:• Described
Page 27 and 28: • The common pyrimidine ribonucle
Page 29 and 30: Glutamine + HCO 3 + 2 ATPO2-H 2 N-C
Page 31 and 32: DihydroorotaseOCHN CH 2O=CNHCH-COO
Page 33 and 34: HNO=COCNCHC-COO -PPiPRPPOrotatePhos
Page 35: KinasesHNO=COCNCHCH2 ATP2 ADPUridin
Page 39 and 40: • Deoxyribonucleotides are synthe
Page 41 and 42: dTMP is formed from dUMP:UMPUDPdUDP
Page 43 and 44: HNOCCHOCHN C-CH 3dUMPO=CNCHO=CNCHdT
Page 45 and 46: • Many anticancer drugs target DN

Biosynthesis of Nucleotides Biosynthesis of Nucleotides - Ecu

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