Biosynthesis of Nucleotides Biosynthesis of Nucleotides - Ecu
Biosynthesis of Nucleotides Biosynthesis of Nucleotides - Ecu
Biosynthesis of Nucleotides Biosynthesis of Nucleotides - Ecu
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• Many anticancer drugs target DNAsynthesis; particularly thymidylatesynthesis• Methotrexate and aminopterin inhibitdihydr<strong>of</strong>olate reductase; thymidylatecannot be formed thus DNA cannot bereplicated• 5-Fluorouracil is converted to 5-Fluorodeoxy-uridylate which binds tightly to thymidylasesynthase and inhibits the enzyme.