Biosynthesis of Nucleotides Biosynthesis of Nucleotides - Ecu

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dTMP can also be synthesized viasalvage of thymidine:ThymidineATPADPThymidinekinasedTMPRadioactive thymidine is used for monitoringintracellular synthesis of DNA because it enters cellseasily and its principle metabolic fate is salvageleading to incorporation into DNA.
• Many anticancer drugs target DNAsynthesis; particularly thymidylatesynthesis• Methotrexate and aminopterin inhibitdihydrofolate reductase; thymidylatecannot be formed thus DNA cannot bereplicated• 5-Fluorouracil is converted to 5-Fluorodeoxy-uridylate which binds tightly to thymidylasesynthase and inhibits the enzyme.
Page 1 and 2: Biosynthesis ofNucleotides
Page 3 and 4: Two Pathways for NucleotideBiosynth
Page 5 and 6: Origin of ring atoms of purines:CO
Page 7 and 8: Phosphoribosylpyrophosphate (PRPP)
Page 9 and 10: O=CNH 2CH 2 NHCHO
Page 11 and 12: H 2 NHCCNNCH
Page 13 and 14: COO-OHC-NHCH 2COO-CH 2 NCCNNCH
Page 15 and 16: OH 2 NCO=CH-NHCCNNCH
Page 17 and 18: - OOC-CH 2-CH-COO -HNHCOCNIMPCCNNCH
Page 19 and 20: OHNHCOCNIMPCCNNCHNADHNAD + IMP D’
Page 21 and 22: Regulation of Purine Biosynthesis:
Page 23 and 24: AMPPPiAdeninephosphoribosyltransfer
Page 25 and 26: Lesch-Nyhan Syndrome:• Described
Page 27 and 28: • The common pyrimidine ribonucle
Page 29 and 30: Glutamine + HCO 3 + 2 ATPO2-H 2 N-C
Page 31 and 32: DihydroorotaseOCHN CH 2O=CNHCH-COO
Page 33 and 34: HNO=COCNCHC-COO -PPiPRPPOrotatePhos
Page 35 and 36: KinasesHNO=COCNCHCH2 ATP2 ADPUridin
Page 37 and 38: Mammalian pyrimidine synthesis is a
Page 39 and 40: • Deoxyribonucleotides are synthe
Page 41 and 42: dTMP is formed from dUMP:UMPUDPdUDP
Page 43: HNOCCHOCHN C-CH 3dUMPO=CNCHO=CNCHdT

Biosynthesis of Nucleotides Biosynthesis of Nucleotides - Ecu

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