Biosynthesis of Nucleotides Biosynthesis of Nucleotides - Ecu

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Regulation of Pyrimidine Biosynthesis:• Carbamoyl phosphate synthetase II isallosterically activated by PRPP and ATP.Pyrimidine nucleotides (UDP, UTP)inhibit.• Aspartate transcarbamoylase (ATCase)from E. coli is inhibited by pyrimidinenucleotides (CTP and UTP). ATP is anallosteric activator.
• Deoxyribonucleotides are synthesized byreduction of ribonucleosides• All 4 ribonucleoside diphosphates (ADP,GDP, CDP, UDP) are substrates forRibonucleotide Reductase• Ribonucleotide Reductase has both a catalytic siteand two allosteric sites. One allosteric site (Activitysite) controls activity at the catalytic site. Thesecond (Specificity site) determines whichnucleoside diphosphate binds the active site.
Page 1 and 2: Biosynthesis ofNucleotides
Page 3 and 4: Two Pathways for NucleotideBiosynth
Page 5 and 6: Origin of ring atoms of purines:CO
Page 7 and 8: Phosphoribosylpyrophosphate (PRPP)
Page 9 and 10: O=CNH 2CH 2 NHCHO
Page 11 and 12: H 2 NHCCNNCH
Page 13 and 14: COO-OHC-NHCH 2COO-CH 2 NCCNNCH
Page 15 and 16: OH 2 NCO=CH-NHCCNNCH
Page 17 and 18: - OOC-CH 2-CH-COO -HNHCOCNIMPCCNNCH
Page 19 and 20: OHNHCOCNIMPCCNNCHNADHNAD + IMP D’
Page 21 and 22: Regulation of Purine Biosynthesis:
Page 23 and 24: AMPPPiAdeninephosphoribosyltransfer
Page 25 and 26: Lesch-Nyhan Syndrome:• Described
Page 27 and 28: • The common pyrimidine ribonucle
Page 29 and 30: Glutamine + HCO 3 + 2 ATPO2-H 2 N-C
Page 31 and 32: DihydroorotaseOCHN CH 2O=CNHCH-COO
Page 33 and 34: HNO=COCNCHC-COO -PPiPRPPOrotatePhos
Page 35 and 36: KinasesHNO=COCNCHCH2 ATP2 ADPUridin
Page 37: Mammalian pyrimidine synthesis is a
Page 41 and 42: dTMP is formed from dUMP:UMPUDPdUDP
Page 43 and 44: HNOCCHOCHN C-CH 3dUMPO=CNCHO=CNCHdT
Page 45 and 46: • Many anticancer drugs target DN

Biosynthesis of Nucleotides Biosynthesis of Nucleotides - Ecu

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